In this paper, poisonous plants and animals which live in our geographical area are listed and described. The most significant poisonous plants in our area are belladonna or deadly nightshade (Atropa belladonna), European scopolia or henbane bell (Scopolia carniolica), nicotiana (Nicotiana alata), mandrake (Mandragora officinarum), jimson weed (Datura stramonium), Christmas rose or black hellebore, (Helleborus niger) and autumn crocus or meadow saffron (Colchicum autumnale) The majority of dangerous plants are a part of the family of nightshades (Solanaceae). They are rich with tropane alkaloids, which serve as anticholinergic substance. They have antagonistic effect on muscarinic acetylcholine receptors. Considering the fact that the muscarinic acetylcholine receptors are widespread in the body during the intoxication with these plants, multiple symptoms are present. They include the disturbance in heart rate and rhythm, inhibition or stimulation of secretion of glands and disorders of intestinal motility. One of the most famous effects is the occurrence of delirium and hallucinations due to the inhibition of the muscarinic acetylcholine receptors in the brain. Poisonous mushrooms are described as well, even though they belong to a separate kingdom. In our area, the most significant ones are death cap (Amanita phalloides) and fly agaric (Amanita muscaria). They belong to the Amanita genus, which are considered the most poisonous. In most cases of mushroom poisoning, death cap (Amanita phalloides) is responsible. In Amanita genus, we can find two different toxin groups: phallotoxins, which causes gastrointestinal issues and amatoxins, which inhibit RNA polymerase II and thus disable the synthesis of vitally important proteins. Animals make the biggest kingdom. From animal toxins, snake toxins, spider toxin and fish toxins are described. The majority of poisonous snakes belong to the family Viperidae. Our most famous poisonous snakes are horned viper (Vipera ammodytes) and common European adder (Vipera berus). Their toxin contains hyaluronidase, which increases reabsorption of substances on the bitten area, phospholipases A2, which causes necrosis of muscle tissue, metalloproteinase, responsible for the decomposition of basilar membrane and proteolytic enzymes which damages capillary endothelium and surrounding tissue. From spiders, black widow (Latrodectus tredecimguttatus) and Mediterranean recluse spider (Loxosceles rufescens) are described. Spider poison is a mixture of monoamines which act proalgetically, peptides with excitatory effects which elicit a nociceptive response and initiate an inflammatory reaction from enzymes sphingomyelins, phospholipases A2 and hyaluronidase. Our most famous poisonous fish are scorpionfish (Scorpanea scrofa) and greater weever (Trachinus draco).