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Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review
Genes, 13 (2022), 6; 949. https://doi.org/10.3390/genes13060949
Molnar, Vilim; Pavelić, Eduard; Vrdoljak, Kristijan; Čemerin, Martin; Klarić, Emil; Matišić, Vid; Bjelica, Roko; Brlek, Petar; Kovačić, Ivana; Tremolada, Carlo; Primorac, Dragan

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Molnar, V., Pavelić, E., Vrdoljak, K., Čemerin, M., Klarić, E., Matišić, V. ... Primorac, D. (2022). Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review. Genes, 13. (6). doi: 10.3390/genes13060949

Molnar, Vilim, et al. "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review." Genes, vol. 13, br. 6, 2022. https://doi.org/10.3390/genes13060949

Molnar, Vilim, Eduard Pavelić, Kristijan Vrdoljak, Martin Čemerin, Emil Klarić, Vid Matišić, Roko Bjelica, et al. "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review." Genes 13, br. 6 (2022). https://doi.org/10.3390/genes13060949

Molnar, V., et al. (2022) 'Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review', Genes, 13(6). doi: 10.3390/genes13060949

Molnar V, Pavelić E, Vrdoljak K, Čemerin M, Klarić E, Matišić V, i sur.. Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review. Genes [Internet]. 2022. [pristupljeno 02.12.2024.];13(6). doi: 10.3390/genes13060949

V. Molnar, et al., "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review", Genes, vol. 13, br. 6, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:643341. [Citirano: 02.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:643341
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Naslov (engleski)Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review
AutorVilim Molnar
AutorEduard Pavelić
AutorKristijan Vrdoljak
AutorMartin Čemerin
AutorEmil Klarić
AutorVid Matišić
AutorRoko Bjelica
AutorPetar Brlek
AutorIvana Kovačić
AutorCarlo Tremolada
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis (OA), alternatives have been sought. Furthermore, the inability of current medications to arrest disease progression has led to rapidly growing clinical research relating to mesenchymal stem cells (MSCs). The availability and function of MSCs vary according to tissue source. The three primary sources include the placenta, bone marrow, and adipose tissue, all of which offer excellent safety profiles. The primary mechanisms of action are trophic and immunomodulatory effects, which prevent the further degradation of joints. However, the function and degree to which benefits are observed vary significantly based on the exosomes secreted by MSCs. Paracrine and autocrine mechanisms prevent cell apoptosis and tissue fibrosis, initiate angiogenesis, and stimulate mitosis via growth factors. MSCs have even been shown to exhibit antimicrobial effects. Clinical results incorporating clinical scores and objective radiological imaging have been promising, but a lack of standardization in isolating MSCs prevents their incorporation in current guidelines.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 13, br. 6, 949
p-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13060949
URN:NBNurn:nbn:hr:184:643341
Datum objave publikacije2022
URL dokumentahttp://bib.irb.hr/1202160
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-29 08:01:36