prikaz prve stranice dokumenta Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
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Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
Anesthesia and analgesia, 69 (1989), 5; 570-574. urn:nbn:hr:184:056514
Radošević-Stašić, Biserka; Udović-Širola, Marija; Stojanov, Lovorka; Ribarić, Ljubomir; Rukavina, Daniel

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Radošević Stašić, B., Udović Širola, M., Stojanov, L., Ribarić, Lj. i Rukavina, D. (1989). Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress. Anesthesia and analgesia, 69. (5), 570-574. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, Biserka, et al. "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress." Anesthesia and analgesia, vol. 69, br. 5, 1989, str. 570-574. https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, Biserka, Marija Udović Širola, Lovorka Stojanov, Ljubomir Ribarić i Daniel Rukavina. "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress." Anesthesia and analgesia 69, br. 5 (1989): 570-574. https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, B., et al. (1989) 'Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress', Anesthesia and analgesia, 69(5), str. 570-574. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:056514 (Datum pristupa: 23.10.2024.)

Radošević Stašić B, Udović Širola M, Stojanov L, Ribarić Lj, Rukavina D. Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress. Anesthesia and analgesia [Internet]. 1989. [pristupljeno 23.10.2024.];69(5):570-574. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:056514

B. Radošević Stašić, M. Udović Širola, L. Stojanov, Lj. Ribarić i D. Rukavina, "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress", Anesthesia and analgesia, vol. 69, br. 5, str. 570-574, 1989. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:056514. [Citirano: 23.10.2024.]

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Podaci o radu
Naslov (engleski)Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
AutorBiserka Radošević-Stašić
AutorMarija Udović-Širola
MBZ: 146291
AutorLovorka Stojanov
AutorLjubomir Ribarić
MBZ: 134591
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
The present study was designed to clarify mechanisms involved in suppression of cell-mediated immunity reported in patients undergoing major surgery with general anesthesia by determining the effects of halothane anesthesia with and without surgery on the growth of Sarcoma I (Sa I), a tumor allogeneic to BALB/c mice. Mice were given subcutaneous injections of 5 × 106 tumor cells from A/Jax mice and then immediately exposed to 0.5%-1.0% halothane for 1 hr without surgery (n = 7) or with surgery (midline laparotomy ; n = 12). In control groups mice were also injected with tumor cells but were not exposed to prolonged halothane anesthesia. Some of them received only Sa 1 (n = 6), while the rest (n = 7) were also laparotomized. The rejection time of Sa I in mice exposed to halothane anesthesia was significantly longer (15.4 ± 1.25 days) than in untreated controls (12.10 ± 0.68 days) (P < 0.05). In the mice exposed to halothane tumor growth was also greater. Surgical stress per se did not significantly affect growth or rejection time of Sa I(11.0 ± 0.66 vs 12.0 ± 0.68 days). Similarly, the combination of surgical stress with halothane anesthesia did not affect the immunosuppression associated with halothane alone (12.9 ± 1.3 vs 15.4 ± 1.25 ; P < 0.05). The results indicate that halothane anesthesia per se may be associated with impairment of cell-mediated immunity under experimental conditions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnesthesia and analgesia
Brojčani podacivol. 69, br. 5, str. 570-574
p-ISSN0003-2999
URN:NBNurn:nbn:hr:184:056514
Datum objave publikacije1989
URL dokumentahttp://bib.irb.hr/195084
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-14 07:06:37