prikaz prve stranice dokumenta The role of perforin-mediated apoptosis in lichen planus lesions
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The role of perforin-mediated apoptosis in lichen planus lesions
Archives of Dermatological Research, 296 (2004), 5; 226-230. https://doi.org/10.1007/s00403-004-0512-1
Kaštelan, Marija; Prpić Massari, Larisa; Gruber, Franjo; Zamolo, Gordana; Žauhar, Gordana; Čoklo, Miran; Rukavina, Danijel

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Kaštelan, M., Prpić Massari, L., Gruber, F., Zamolo, G., Žauhar, G., Čoklo, M. i Rukavina, D. (2004). The role of perforin-mediated apoptosis in lichen planus lesions. Archives of Dermatological Research, 296. (5), 226-230. doi: 10.1007/s00403-004-0512-1

Kaštelan, Marija, et al. "The role of perforin-mediated apoptosis in lichen planus lesions." Archives of Dermatological Research, vol. 296, br. 5, 2004, str. 226-230. https://doi.org/10.1007/s00403-004-0512-1

Kaštelan, Marija, Larisa Prpić Massari, Franjo Gruber, Gordana Zamolo, Gordana Žauhar, Miran Čoklo i Danijel Rukavina. "The role of perforin-mediated apoptosis in lichen planus lesions." Archives of Dermatological Research 296, br. 5 (2004): 226-230. https://doi.org/10.1007/s00403-004-0512-1

Kaštelan, M., et al. (2004) 'The role of perforin-mediated apoptosis in lichen planus lesions', Archives of Dermatological Research, 296(5), str. 226-230. doi: 10.1007/s00403-004-0512-1

Kaštelan M, Prpić Massari L, Gruber F, Zamolo G, Žauhar G, Čoklo M, i sur.. The role of perforin-mediated apoptosis in lichen planus lesions. Archives of Dermatological Research [Internet]. 2004. [pristupljeno 04.12.2024.];296(5):226-230. doi: 10.1007/s00403-004-0512-1

M. Kaštelan, et al., "The role of perforin-mediated apoptosis in lichen planus lesions", Archives of Dermatological Research, vol. 296, br. 5, str. 226-230, 2004. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:661425. [Citirano: 04.12.2024.]

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Naslov (engleski)The role of perforin-mediated apoptosis in lichen planus lesions
AutorMarija Kaštelan
AutorLarisa Prpić Massari
AutorFranjo Gruber
AutorGordana Zamolo
AutorGordana Žauhar
AutorMiran Čoklo
AutorDanijel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku fiziku i biofiziku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArchives of Dermatological Research
Brojčani podacivol. 296, br. 5, str. 226-230
p-ISSN0340-3696
e-ISSN1432-069X
DOIhttps://doi.org/10.1007/s00403-004-0512-1
URN:NBNurn:nbn:hr:184:661425
Datum objave publikacije2004
URL dokumentahttp://link.springer.com/10.1007/s00403-004-0512-1
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-12 07:38:04