prikaz prve stranice dokumenta NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
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NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
Journal of Experimental Medicine, 218 (2021), 5; 1-14. https://doi.org/10.1084/jem.20201503
Kveštak, Daria; Juranić Lisnić, Vanda; Lisnić, Berislav; Tomac, Jelena; Golemac, Mijo; Brizić, Ilija; Indenbirken, Daniela; Cokarić Brdovčak, Maja; Bernardini, Giovanni; Krstanović, Fran; Rožmanić, Carmen; Grundhoff, Adam; Krmpotić, Astrid; Britt, William J.; Jonjić, Stipan Više autora...

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Kveštak, D., Juranić Lisnić, V., Lisnić, B., Tomac, J., Golemac, M., Brizić, I. ... Jonjić, S. (2021). NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. Journal of Experimental Medicine, 218. (5), 1-14. doi: 10.1084/jem.20201503

Kveštak, Daria, et al. "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection." Journal of Experimental Medicine, vol. 218, br. 5, 2021, str. 1-14. https://doi.org/10.1084/jem.20201503

Kveštak, Daria, Vanda Juranić Lisnić, Berislav Lisnić, Jelena Tomac, Mijo Golemac, Ilija Brizić, Daniela Indenbirken, et al. "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection." Journal of Experimental Medicine 218, br. 5 (2021): 1-14. https://doi.org/10.1084/jem.20201503

Kveštak, D., et al. (2021) 'NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection', Journal of Experimental Medicine, 218(5), str. 1-14. doi: 10.1084/jem.20201503

Kveštak D, Juranić Lisnić V, Lisnić B, Tomac J, Golemac M, Brizić I, i sur.. NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. Journal of Experimental Medicine [Internet]. 03.05.2021. [pristupljeno 04.12.2024.];218(5):1-14. doi: 10.1084/jem.20201503

D. Kveštak, et al., "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection", Journal of Experimental Medicine, vol. 218, br. 5, str. 1-14, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:755338. [Citirano: 04.12.2024.]

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Naslov (engleski)NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
AutorDaria Kveštak
AutorVanda Juranić Lisnić
AutorBerislav Lisnić
AutorJelena Tomac
AutorMijo Golemac
AutorIlija Brizić
AutorDaniela Indenbirken
AutorMaja Cokarić Brdovčak
AutorGiovanni Bernardini
AutorFran Krstanović
AutorCarmen Rožmanić
AutorAdam Grundhoff
AutorAstrid Krmpotić
AutorWilliam J. Britt
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Congenital human cytomegalovirus (cHCMV) infection of the brain is associated with a wide range of neurocognitive sequelae. Using infection of newborn mice with mouse cytomegalovirus (MCMV) as a reliable model that recapitulates many aspects of cHCMV infection, including disseminated infection, CNS infection, altered neurodevelopment, and sensorineural hearing loss, we have previously shown that mitigation of inflammation prevented alterations in cerebellar development, suggesting that host inflammatory factors are key drivers of neurodevelopmental defects. Here, we show that MCMV infection causes a dramatic increase in the expression of the microglia-derived chemokines CXCL9/CXCL10, which recruit NK and ILC1 cells into the brain in a CXCR3-dependent manner. Surprisingly, brain-infiltrating innate immune cells not only were unable to control virus infection in the brain but also orchestrated pathological inflammatory responses, which lead to delays in cerebellar morphogenesis. Our results identify NK and ILC1 cells as the major mediators of immunopathology in response to virus infection in the developing CNS, which can be prevented by anti–IFN-γ antibodies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prethodno/kratko priopćenje
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 218, br. 5, str. 1-14, e20201503
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20201503
URN:NBNurn:nbn:hr:184:755338
Datum objave publikacije2021-05-03
ProjektŠifra: uniri-biomed-18-234
Naziv (hrvatski): Transkriptomska analiza mikroglije nakon infekcije citomegalovirusom
Naziv (engleski): Transcriptomic analysis of microglia following cytomegalovirus infection
Voditelj: Berislav Lisnić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: IP-2018-01-9086
Naziv (hrvatski): Novi pristup razvoju cjepiva za kongenitalnu citomegalovirusnu infekciju
Naziv (engleski): New Approach for Development of Vaccine for Cytomegalovirus Infection
Kratica: VaccongCMV
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: 1R56DC015980-01
Naziv (engleski): Inflammation and Hearing Loss Following Congenital CMV Infection
Voditelj: Stipan Jonjić
Pravna nadležnost: Sjedinjene Američke Države
Financijer: NIH
Linija financiranja: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://rupress.org/jem/article/doi/10.1084/jem.20201503/211828/NK-ILC1-cells-mediate-neuroinflammation-and-brain
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2022-04-08 13:58:50