prikaz prve stranice dokumenta Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
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Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
Cellular & Molecular Immunology, 12 (2014), 2; 180-191. https://doi.org/10.1038/cmi.2014.51
Slavuljica, Irena; Kveštak, Daria; Csaba Huszthy, Peter; Kosmac, Kate; Britt, William J; Jonjić, Stipan

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Slavuljica, I., Kveštak, D., Csaba Huszthy, P., Kosmac, K., Britt, W. J. i Jonjić, S. (2014). Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model. Cellular & Molecular Immunology, 12. (2), 180-191. doi: 10.1038/cmi.2014.51

Slavuljica, Irena, et al. "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model." Cellular & Molecular Immunology, vol. 12, br. 2, 2014, str. 180-191. https://doi.org/10.1038/cmi.2014.51

Slavuljica, Irena, Daria Kveštak, Peter Csaba Huszthy, Kate Kosmac, William J Britt i Stipan Jonjić. "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model." Cellular & Molecular Immunology 12, br. 2 (2014): 180-191. https://doi.org/10.1038/cmi.2014.51

Slavuljica, I., et al. (2014) 'Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model', Cellular & Molecular Immunology, 12(2), str. 180-191. doi: 10.1038/cmi.2014.51

Slavuljica I, Kveštak D, Csaba Huszthy P, Kosmac K, Britt WJ, Jonjić S. Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model. Cellular & Molecular Immunology [Internet]. 2014. [pristupljeno 04.12.2024.];12(2):180-191. doi: 10.1038/cmi.2014.51

I. Slavuljica, D. Kveštak, P. Csaba Huszthy, K. Kosmac, W. J. Britt i S. Jonjić, "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model", Cellular & Molecular Immunology, vol. 12, br. 2, str. 180-191, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:378634. [Citirano: 04.12.2024.]

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Naslov (engleski)Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
AutorIrena Slavuljica
AutorDaria Kveštak
AutorPeter Csaba Huszthy
AutorKate Kosmac
AutorWilliam J Britt
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Congenital human cytomegalovirus infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and hearing defects. Strict species specificity of cytomegaloviruses has restricted the scope of studies of cytomegalovirus infection in animal models. To investigate the pathogenesis of congenital human cytomegalovirus infection, we developed a mouse cytomegalovirus model that recapitulates the major characteristics of central nervous system infection in human infants, including the route of neuroinvasion and neuropathological findings. Following intraperitoneal inoculation of newborn animals with mouse cytomegalovirus, the virus disseminates to the central nervous system during high-level viremia and replicates in the brain parenchyma, resulting in a focal but widespread, non-necrotizing encephalitis. Central nervous system infection is coupled with the recruitment of resident and peripheral immune cells as well as the expression of a large number of pro-inflammatory cytokines. Although infiltration of cellular constituents of the innate immune response characterizes the early immune response in the central nervous system, resolution of productive infection requires virus-specific CD8(+) T cells. Perinatal mouse cytomegalovirus infection results in profoundly altered postnatal development of the mouse central nervous system and long-term motor and sensory disabilities. Based on an enhanced understanding of the pathogenesis of this infection, prospects for novel intervention strategies aimed to improve the outcome of congenital human cytomegalovirus infection are proposed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCellular & Molecular Immunology
Brojčani podacivol. 12, br. 2, str. 180-191
p-ISSN1672-7681
e-ISSN2042-0226
DOIhttps://doi.org/10.1038/cmi.2014.51
URN:NBNurn:nbn:hr:184:378634
Datum objave publikacije2014
ProjektŠifra: 1R01NS065845-01A1
Naziv (engleski): MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control
Voditelj: Stipan Jonjić
Pravna nadležnost: Sjedinjene Američke Države
Financijer: NIH
Linija financiranja: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
ProjektŠifra: 1RO1AI083201-01
Naziv (engleski): Viral evasion of NK cells
Voditelj: Stipan Jonjić
Pravna nadležnost: Sjedinjene Američke Države
Financijer: NIH
URL dokumentahttp://www.nature.com/articles/cmi201451
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-08 13:12:10