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Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences
Genes, 12 (2021), 12; 1999. https://doi.org/10.3390/genes12121999
Zenic, Lucija; Polančec, Denis; Hudetz, Damir; Jeleč, Željko; Rod, Eduard; Vidović, Dinko; Starešinić, Mario; Sabalic, Srećko; Vrdoljak, Trpimir; Petrović, Tadija; Cukelj, Fabijan; Molnar, Vilim; Cemerin, Martin; Matišić, Vid; Brlek, Petar; Djukić Koroljević, Zrinka; Borić, Igor; Lauc, Gordan; Primorac, Dragan Više autora...

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Zenic, L., Polančec, D., Hudetz, D., Jeleč, Ž., Rod, E., Vidović, D. ... Primorac, D. (2021). Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences. Genes, 12. (12), 1. doi: 10.3390/genes12121999

Zenic, Lucija, et al. "Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences." Genes, vol. 12, br. 12, 2021, str. 1. https://doi.org/10.3390/genes12121999

Zenic, Lucija, Denis Polančec, Damir Hudetz, Željko Jeleč, Eduard Rod, Dinko Vidović, Mario Starešinić, et al. "Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences." Genes 12, br. 12 (2021): 1. https://doi.org/10.3390/genes12121999

Zenic, L., et al. (2021) 'Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences', Genes, 12(12), str. 1. doi: 10.3390/genes12121999

Zenic L, Polančec D, Hudetz D, Jeleč Ž, Rod E, Vidović D, i sur.. Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences. Genes [Internet]. 16.12.2021. [pristupljeno 02.12.2024.];12(12):1. doi: 10.3390/genes12121999

L. Zenic, et al., "Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences", Genes, vol. 12, br. 12, str. 1, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:793998. [Citirano: 02.12.2024.]

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Podaci o radu
Naslov (engleski)Polychromatic Flow Cytometric Analysis of Stromal Vascular Fraction from Lipoaspirate and Microfragmented Counterparts Reveals Sex-Related Immunophenotype Differences
AutorLucija Zenic
AutorDenis Polančec
AutorDamir Hudetz
AutorŽeljko Jeleč
AutorEduard Rod
AutorDinko Vidović
AutorMario Starešinić
AutorSrećko Sabalic
AutorTrpimir Vrdoljak
AutorTadija Petrović
AutorFabijan Cukelj
AutorVilim Molnar
AutorMartin Cemerin
AutorVid Matišić
AutorPetar Brlek
AutorZrinka Djukić Koroljević
AutorIgor Borić
AutorGordan Lauc
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Sažetak (engleski)
Mesenchymal stem/stromal cells or medicinal signaling cells (MSC)-based therapy holds promise as a beneficial strategy for treating knee OA (osteoarthritis), but there is no standardized protocols nor mechanistic understanding. In order to gain a better insight into the human MSC from adipose tissue applied for autologous OA treatment, we performed extensive comparative immunophenotyping of the stromal vascular fraction from lipoaspirate or microfragmented lipoaspirates by polychromatic flow cytometry and investigated the cellular components considered responsible for cartilage regeneration. We found an enrichment of the regenerative cellular niche of the clinically applied microfragmented stromal vascular fraction. Sex-related differences were observed in the MSC marker expression and the ratio of the progenitor cells from fresh lipoaspirate, which, in female patients, contained a higher expression of CD90 on the three progenitor cell types including pericytes, a higher expression of CD105 and CD146 on CD31highCD34high endothelial progenitors as well as of CD73 on supra-adventitialadipose stromal cells. Some of these MSC-expression differences were present after microfragmentation and indicated a differential phenotype pattern of the applied MSC mixture in female and male patients. Our results provide a better insight into the heterogeneity of the adipose MSC subpopulations serving as OA therapeutics, with an emphasis on interesting differences between women and men.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 12, br. 12, str. 1, 1999
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes12121999
URN:NBNurn:nbn:hr:184:793998
Datum objave publikacije2021-12-16
URL dokumentahttps://www.mdpi.com/2073-4425/12/12/1999
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-07 14:03:13