prikaz prve stranice dokumenta Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
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Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
Molecular immunology, 47 (2009), 1; 114-122. https://doi.org/10.1016/j.molimm.2009.02.010
Arapović, Jurica; Lenac Roviš, Tihana; Reddy, A.B.; Krmpotić, Astrid; Jonjić, Stipan

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Arapović, J., Lenac Roviš, T., Reddy, A., Krmpotić, A. i Jonjić, S. (2009). Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Molecular immunology, 47. (1), 114-122. doi: 10.1016/j.molimm.2009.02.010

Arapović, Jurica, et al. "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60." Molecular immunology, vol. 47, br. 1, 2009, str. 114-122. https://doi.org/10.1016/j.molimm.2009.02.010

Arapović, Jurica, Tihana Lenac Roviš, A.B. Reddy, Astrid Krmpotić i Stipan Jonjić. "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60." Molecular immunology 47, br. 1 (2009): 114-122. https://doi.org/10.1016/j.molimm.2009.02.010

Arapović, J., et al. (2009) 'Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60', Molecular immunology, 47(1), str. 114-122. doi: 10.1016/j.molimm.2009.02.010

Arapović J, Lenac Roviš T, Reddy A, Krmpotić A, Jonjić S. Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Molecular immunology [Internet]. 2009. [pristupljeno 24.12.2024.];47(1):114-122. doi: 10.1016/j.molimm.2009.02.010

J. Arapović, T. Lenac Roviš, A. Reddy, A. Krmpotić i S. Jonjić, "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60", Molecular immunology, vol. 47, br. 1, str. 114-122, 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:193906. [Citirano: 24.12.2024.]

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Naslov (engleski)Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
AutorJurica Arapović
AutorTihana Lenac Roviš
AutorA.B. Reddy
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Both human and mouse cytomegalovirus (CMV) encode proteins that inhibit the activation of NK cells by down-regulating the cellular ligands for activating NK cell receptor, NKG2D. MCMV proteins m145, m152 and m155 interfere with the expression of all known NKG2D ligands, MULT-1, RAE-1 family members and H60, respectively, whereas m138 affects the expression of MULT-1 and H60. Here we show that m152 affects the maturation of newly synthesized RAE-1 molecules, but is not sufficient to prevent surface expression of RAE-1varepsilon. We have identified m138 as a main inhibitor of the surface expression of RAE-1varepsilon. In contrast to m152, m138 affects the surface-resident protein leading to its endocytosis, which can be prevented by a dynamin inhibitor. Moreover, we demonstrated that m138 does not need other viral proteins to down-modulate the expression of RAE-1varepsilon.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular immunology
Brojčani podacivol. 47, br. 1, str. 114-122
p-ISSN0161-5890
DOIhttps://doi.org/10.1016/j.molimm.2009.02.010
URN:NBNurn:nbn:hr:184:193906
Datum objave publikacije2009
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Naziv (engleski): Molecular mechanisms of immune evasion by cytomegalovirus
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621261-1268
Naziv (hrvatski): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Naziv (engleski): The role of cytomegalovirus immunoevasion genes in latency
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/442663
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-03-24 14:57:53