prikaz prve stranice dokumenta Altered development of the brain after focal herpesvirus infection of the central nervous system
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Altered development of the brain after focal herpesvirus infection of the central nervous system
Journal of Experimental Medicine, 205 (2008), 2; 423-435. https://doi.org/10.1084/jem.20071489
Koontz, Thad; Bralić, Marina; Tomac, Jelena; Pernjak-Pugel, Ester; Bantug, Glenn Robert; Jonjić, Stipan; Britt, William J.

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Koontz, T., Bralić, M., Tomac, J., Pernjak Pugel, E., Bantug, G. R., Jonjić, S. i Britt, W. J. (2008). Altered development of the brain after focal herpesvirus infection of the central nervous system. Journal of Experimental Medicine, 205. (2), 423-435. doi: 10.1084/jem.20071489

Koontz, Thad, et al. "Altered development of the brain after focal herpesvirus infection of the central nervous system." Journal of Experimental Medicine, vol. 205, br. 2, 2008, str. 423-435. https://doi.org/10.1084/jem.20071489

Koontz, Thad, Marina Bralić, Jelena Tomac, Ester Pernjak Pugel, Glenn Robert Bantug, Stipan Jonjić i William J. Britt. "Altered development of the brain after focal herpesvirus infection of the central nervous system." Journal of Experimental Medicine 205, br. 2 (2008): 423-435. https://doi.org/10.1084/jem.20071489

Koontz, T., et al. (2008) 'Altered development of the brain after focal herpesvirus infection of the central nervous system', Journal of Experimental Medicine, 205(2), str. 423-435. doi: 10.1084/jem.20071489

Koontz T, Bralić M, Tomac J, Pernjak Pugel E, Bantug GR, Jonjić S, i sur.. Altered development of the brain after focal herpesvirus infection of the central nervous system. Journal of Experimental Medicine [Internet]. 18.02.2008. [pristupljeno 21.10.2024.];205(2):423-435. doi: 10.1084/jem.20071489

T. Koontz, et al., "Altered development of the brain after focal herpesvirus infection of the central nervous system", Journal of Experimental Medicine, vol. 205, br. 2, str. 423-435, Veljača 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:067755. [Citirano: 21.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:067755
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Naslov (engleski)Altered development of the brain after focal herpesvirus infection of the central nervous system
AutorThad Koontz
AutorMarina Bralić
AutorJelena Tomac
AutorEster Pernjak-Pugel
AutorGlenn Robert Bantug
AutorStipan Jonjić
AutorWilliam J. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus infection of the developing central nervous system (CNS) is a major cause of neurological damage in newborn infants and children. To investigate the pathogenesis of this human infection, we developed a mouse model of infection in the developing CNS. Intraperitoneal inoculation of newborn animals with murine cytomegalovirus resulted in virus replication in the liver followed by virus spread to the brain. Virus infection of the CNS was associated with the induction of inflammatory responses, including the induction of a large number of interferon-stimulated genes and histological evidence of focal encephalitis with recruitment of mononuclear cells to foci containing virus-infected cells. The morphogenesis of the cerebellum was delayed in infected animals. The defects in cerebellar development in infected animals were generalized and, although correlated temporally with virus replication and CNS inflammation, spatially unrelated to foci of virus-infected cells. Specific defects included decreased granular neuron proliferation and migration, expression of differentiation markers, and activation of neurotrophin receptors. These findings suggested that in the developing CNS, focal virus infection and induction of inflammatory responses in resident and infiltrating mononuclear cells resulted in delayed cerebellar morphogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 205, br. 2, str. 423-435
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20071489
URN:NBNurn:nbn:hr:184:067755
Datum objave publikacije2008-02-18
URL dokumentahttps://rupress.org/jem/article/205/2/423/40267/Altered-development-of-the-brain-after-focal
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-18 14:48:52