prikaz prve stranice dokumenta Calpain expression in the brain cortex after traumatic brain injury
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Calpain expression in the brain cortex after traumatic brain injury
Collegium antropologicum, 36 (2012), 4; 1319-1323. urn:nbn:hr:184:963591
Bralić, Marina; Stemberga, Valter

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Bralić, M. i Stemberga, V. (2012). Calpain expression in the brain cortex after traumatic brain injury. Collegium antropologicum, 36. (4), 1319-1323. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, Marina i Valter Stemberga. "Calpain expression in the brain cortex after traumatic brain injury." Collegium antropologicum, vol. 36, br. 4, 2012, str. 1319-1323. https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, Marina i Valter Stemberga. "Calpain expression in the brain cortex after traumatic brain injury." Collegium antropologicum 36, br. 4 (2012): 1319-1323. https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, M. i Stemberga, V. (2012) 'Calpain expression in the brain cortex after traumatic brain injury', Collegium antropologicum, 36(4), str. 1319-1323. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:963591 (Datum pristupa: 12.11.2024.)

Bralić M, Stemberga V. Calpain expression in the brain cortex after traumatic brain injury. Collegium antropologicum [Internet]. 2012. [pristupljeno 12.11.2024.];36(4):1319-1323. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:963591

M. Bralić i V. Stemberga, "Calpain expression in the brain cortex after traumatic brain injury", Collegium antropologicum, vol. 36, br. 4, str. 1319-1323, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:963591. [Citirano: 12.11.2024.]

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Podaci o radu
Naslov (engleski)Calpain expression in the brain cortex after traumatic brain injury
AutorMarina Bralić
AutorValter Stemberga
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za neurologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za sudsku medicinu i kriminalistiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sudska medicina
Sažetak (engleski)
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide. Calpains, a family of cysteine proteases have been implicated in cells death following TBI. Using immunohistochemistry calpain expression was ana- lyzed in post mortem brain tissue obtained from patients who died after TBI, and findings were compared with the brain tissue from patients who died from sudden cardiac arrest. In the injured cortex an increase in calpain expression was ob- served in all resident brain cells: neurons, glial and endothelial cells in comparison to the control group (all p<0.001). Calpain expression was analyzed in different post- traumatic intervals, from day 0 until 10 days post-injury, in order to establish a time course of expression in the brain cortex after TBI. Expression was detected in the cortex 5 hours after the accident, peaked at 72 hours, and substantially reduced by 10 days after TBI. Calpain expression in the cortex signifi- cantly changed during the time from TBI to death (p<0.001), and the most prominent expression was detected in the cor- tex 3 days after TBI. Our results indicate that prolonged calpain expression in resident brain cells (neurons, glial and en- dothelial cells) plays an important role in neuronal degeneration following TBI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 36, br. 4, str. 1319-1323
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:963591
Datum objave publikacije2012
URL dokumentahttp://bib.irb.hr/1119393
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-17 23:08:13