prikaz prve stranice dokumenta Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial
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Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial
Diabetes, Obesity and Metabolism, 22 (2020), 11; 2097-2106. https://doi.org/10.1111/dom.14129
Lukenda Žanko, Vesna; Domislović, Viktor; Trkulja, Vladimir; Krznarić-Zrnić, Irena; Turk-Wensveen, Tamara; Krznarić, Željko; Filipec Kanižaj, Tajana; Radić-Kristo, Delfa; Bilić-Zulle, Lidija; Orlić, Lidija; Dinjar-Kujundžić, Petra; Poropat, Goran; Štimac, Davor; Hauser, Goran; Mikolašević, Ivana Više autora...

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Lukenda Žanko, V., Domislović, V., Trkulja, V., Krznarić Zrnić, I., Turk Wensveen, T., Krznarić, Ž. ... Mikolašević, I. (2020). Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial. Diabetes, Obesity and Metabolism, 22. (11), 2097-2106. doi: 10.1111/dom.14129

Lukenda Žanko, Vesna, et al. "Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial." Diabetes, Obesity and Metabolism, vol. 22, br. 11, 2020, str. 2097-2106. https://doi.org/10.1111/dom.14129

Lukenda Žanko, Vesna, Viktor Domislović, Vladimir Trkulja, Irena Krznarić Zrnić, Tamara Turk Wensveen, Željko Krznarić, Tajana Filipec Kanižaj, et al. "Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial." Diabetes, Obesity and Metabolism 22, br. 11 (2020): 2097-2106. https://doi.org/10.1111/dom.14129

Lukenda Žanko, V., et al. (2020) 'Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial', Diabetes, Obesity and Metabolism, 22(11), str. 2097-2106. doi: 10.1111/dom.14129

Lukenda Žanko V, Domislović V, Trkulja V, Krznarić Zrnić I, Turk Wensveen T, Krznarić Ž, i sur.. Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial. Diabetes, Obesity and Metabolism [Internet]. 2020. [pristupljeno 14.11.2024.];22(11):2097-2106. doi: 10.1111/dom.14129

V. Lukenda Žanko, et al., "Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial", Diabetes, Obesity and Metabolism, vol. 22, br. 11, str. 2097-2106, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:716459. [Citirano: 14.11.2024.]

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Naslov (engleski)Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial
AutorVesna Lukenda Žanko
AutorViktor Domislović
AutorVladimir Trkulja
AutorIrena Krznarić-Zrnić
AutorTamara Turk-Wensveen
AutorŽeljko Krznarić
AutorTajana Filipec Kanižaj
AutorDelfa Radić-Kristo
AutorLidija Bilić-Zulle
AutorLidija Orlić
AutorPetra Dinjar-Kujundžić
AutorGoran Poropat
AutorDavor Štimac
AutorGoran Hauser
AutorIvana Mikolašević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Abstract Aim: To evaluate the effects of vitamin D on transient elastography (TE, FibroScan) indices of liver steatosis (controlled attenuation parameter [CAP]) and fibrosis (liver stiffness measurement [LSM]) in adults with non-alcoholic fatty liver disease (NAFLD). Patients and methods: In this randomized (2:1), double-blind, single-centre, 12-month trial, patients with NAFLD were treated with vitamin D (1000 IU/day) (n = 201) or a matching placebo (n = 110). Two co-primary outcomes were changes in CAP and LSM after 360 days of treatment versus baseline. Two main secondary outcomes were CAP/LSM changes after 180 days of treatment. Results: Both CAP and LSM gradually decreased in vitamin D-treated patients and slightly increased in the placebo arm. Vitamin D was superior to placebo for both primary outcomes (mean differences in CAP and LSM changes (-49.5 dB/m [95% CI -59.5 to -39.4] and -0.72 kPa [95% CI -1.43 to 0.00], respectively) and both secondary outcomes (-22.1 dB/m [-32.1 to -12.1] and -0.89 kPa [-1.61 to -0.17], respectively). Of a number of exploratory outcomes (change at 12 months vs. baseline), vitamin D reduced serum uric acid (-17.9 μmol/L [-30.6 to -5.2]), gamma-glutamyltransferase (-8.9 IU/L [-15.5 to -2.3)] and fasting serum insulin levels (-5.1 pmol/L [-9.3 to -0.8]) as well as the homeostatic model assessment of insulin resistance index (-1.6 [-3.1 to -0.2]) (false discovery rate [5%]-adjusted P-values between .0572 and .0952). Conclusion: Low-medium dose supplementation of vitamin D (1000 IU/day) over 12 months reduces TE indices of liver steatosis (CAP) and fibrosis (LSM) in NAFLD patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiabetes, Obesity and Metabolism
Brojčani podacivol. 22, br. 11, str. 2097-2106
p-ISSN1462-8902
e-ISSN1463-1326
DOIhttps://doi.org/10.1111/dom.14129
URN:NBNurn:nbn:hr:184:716459
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1088454
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-14 14:09:24