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The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma
Pathology, research and practice, 212 (2016), 6; 509-516. https://doi.org/10.1016/j.prp.2015.11.021
Babarović, Emina; Valković, Toni; Budisavljević, Ivana; Balen, Iva; Štifter, Sanja; Duletić-Načinović, Antica; Lučin, Ksenija; Jonjić, Nives

Citirajte ovaj rad

Babarović, E., Valković, T., Budisavljević, I., Balen, I., Štifter, S., Duletić Načinović, A. ... Jonjić, N. (2016). The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology, research and practice, 212. (6), 509-516. doi: 10.1016/j.prp.2015.11.021

Babarović, Emina, et al. "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology, research and practice, vol. 212, br. 6, 2016, str. 509-516. https://doi.org/10.1016/j.prp.2015.11.021

Babarović, Emina, Toni Valković, Ivana Budisavljević, Iva Balen, Sanja Štifter, Antica Duletić Načinović, Ksenija Lučin i Nives Jonjić. "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology, research and practice 212, br. 6 (2016): 509-516. https://doi.org/10.1016/j.prp.2015.11.021

Babarović, E., et al. (2016) 'The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma', Pathology, research and practice, 212(6), str. 509-516. doi: 10.1016/j.prp.2015.11.021

Babarović E, Valković T, Budisavljević I, Balen I, Štifter S, Duletić Načinović A, i sur.. The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology, research and practice [Internet]. 2016. [pristupljeno 02.12.2024.];212(6):509-516. doi: 10.1016/j.prp.2015.11.021

E. Babarović, et al., "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma", Pathology, research and practice, vol. 212, br. 6, str. 509-516, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:347840. [Citirano: 02.12.2024.]

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Naslov (engleski)The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma
AutorEmina Babarović
AutorToni Valković
AutorIvana Budisavljević
AutorIva Balen
AutorSanja Štifter
AutorAntica Duletić-Načinović
AutorKsenija Lučin
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Several studies have shown a gradual increase in the extent of bone marrow angiogenesis in various stages of proliferative plasma cell disorders, from monoclonal gammopathy of undetermined significance (MGUS) to active multiple myeloma (MM). The main aim of this study was to evaluate tumor angiogenesis parameters in detail and to correlate them with the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF) in the bone marrow of patients with MGUS and MM. In addition, we wanted to determine their prognostic significance in active MM. Ninety- five patients were enrolled in the study: 14 diagnosed with MGUS, 13 with asymptomatic myeloma (AMM) and 68 with active MM. Computer assisted image analysis was used to determine the angiogenesis parameters, the quantity of microvessels per 1mm2 (MVD), the area occupied by microvessels per 1mm2 and the percentage of microvessel area in total section area (TVA). Double immunohistochemical methods CD138+VEGF and CD138+OPN were used to evaluate expression of these proteins in plasma cells, and OPN was also analyzed for its interstitial expression (iOPN). A significant positive correlation was determined between VEGF and iOPN with angiogenic parameters in the MGUS stage of the disease. In advanced stages of the disease, a significant negative correlation was recorded between OPN and iOPN with parameters of angiogenesis. Overall survival was significantly shorter for patients with negative iOPN (p=0.002) and higher angiogenic parameters, MVD (p=0.009), TVA (p=0.008) and area of microvessels per 1mm2 (p=0.02). Positive VEGF expression in our model predicted a better three-year survival of patients with active MM (OR: 5.25, p=0.03 ; HR: 0.44, p=0.04). The results of our study suggested a possible key role of VEGF and OPN in the induction of angiogenesis in early-stage disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathology, research and practice
Brojčani podacivol. 212, br. 6, str. 509-516
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2015.11.021
URN:NBNurn:nbn:hr:184:347840
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/812276
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
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Datum i vrijeme pohrane2022-03-10 18:06:28