prikaz prve stranice dokumenta Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
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Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
Food and Chemical Toxicology, 107 (2017); 215-225. https://doi.org/10.1016/j.fct.2017.06.043
Potočnjak, Iva; Broznić, Dalibor; Kindl, Marija; Kropek, Matija; Vladimir-Knežević, Sanda; Domitrović, Robert

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Potočnjak, I., Broznić, D., Kindl, M., Kropek, M., Vladimir Knežević, S. i Domitrović, R. (2017). Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation. Food and Chemical Toxicology, 107., 215-225. doi: 10.1016/j.fct.2017.06.043

Potočnjak, Iva, et al. "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation." Food and Chemical Toxicology, vol. 107, 2017, str. 215-225. https://doi.org/10.1016/j.fct.2017.06.043

Potočnjak, Iva, Dalibor Broznić, Marija Kindl, Matija Kropek, Sanda Vladimir Knežević i Robert Domitrović. "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation." Food and Chemical Toxicology 107 (2017): 215-225. https://doi.org/10.1016/j.fct.2017.06.043

Potočnjak, I., et al. (2017) 'Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation', Food and Chemical Toxicology, 107, str. 215-225. doi: 10.1016/j.fct.2017.06.043

Potočnjak I, Broznić D, Kindl M, Kropek M, Vladimir Knežević S, Domitrović R. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation. Food and Chemical Toxicology [Internet]. 2017. [pristupljeno 14.11.2024.];107:215-225. doi: 10.1016/j.fct.2017.06.043

I. Potočnjak, D. Broznić, M. Kindl, M. Kropek, S. Vladimir Knežević i R. Domitrović, "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation", Food and Chemical Toxicology, vol. 107, str. 215-225, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:956629. [Citirano: 14.11.2024.]

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Podaci o radu
Naslov (engleski)Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
AutorIva Potočnjak
AutorDalibor Broznić
AutorMarija Kindl
MBZ: 327281
AutorMatija Kropek
AutorSanda Vladimir-Knežević
MBZ: 170161
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Sažetak (engleski)
We investigated the effect of natural sweetener Stevia rebaudiana and its constituent stevioside in cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 10, 20, and 50 mg/kg body weight of Stevia rebaudiana ethanol extract (SE) or stevioside 50 mg/kg, 48 h after intraperitoneal administration of CP (13 mg/kg). Two days later, CP treatment resulted in histopathological changes showing kidney injury. Increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), and heme oxygenase-1 (HO-1) in mice kidneys suggested oxidative stress. CP treatment also increased renal expression of nuclear factor-kappaB (NF-κB) p65 subunit and phosphorylated inhibitor of NF-κB (IκBα), as well as expression of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α). Induction of apoptosis and inhibition of the cell cycle in kidneys was evidenced by increased expression of p53, Bax, caspase-9, and p21, proteolytic cleavage of poly (ADP-ribose) polymerase (PARP), with concomitant suppression of Bcl-2 and cyclin D1 expression. The number of apoptotic cells in kidneys was also assessed. CP administration resulted in activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3). Both SE and stevioside attenuated CP nephrotoxicity by suppressing oxidative stress, inflammation, and apoptosis through mechanism involving ERK1/2, STAT3, and NF-κB suppression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFood and Chemical Toxicology
Brojčani podacivol. 107, str. 215-225
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2017.06.043
URN:NBNurn:nbn:hr:184:956629
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/877063
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-08 14:09:13