prikaz prve stranice dokumenta Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
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Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
European Journal of Internal Medicine, 82 (2020); 68-75. https://doi.org/10.1016/j.ejim.2020.08.005
Mikolašević, Ivana; Domislović, V; Turk Wensveen, Tamara; Delija, Božena; Klapan, Mia; Jurić, Toni; Lukić, Anđela; Mijić, A; Skenderević, N; Puž, P; Ostojić, A; Krznarić, Ž; Štimac, Davor

Citirajte ovaj rad

Mikolašević, I., Domislović, V., Turk Wensveen, T., Delija, B., Klapan, M., Jurić, T. ... Štimac, D. (2020). Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study. European Journal of Internal Medicine, 82., 68-75. doi: 10.1016/j.ejim.2020.08.005

Mikolašević, Ivana, et al. "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study." European Journal of Internal Medicine, vol. 82, 2020, str. 68-75. https://doi.org/10.1016/j.ejim.2020.08.005

Mikolašević, Ivana, V Domislović, Tamara Turk Wensveen, Božena Delija, Mia Klapan, Toni Jurić, Anđela Lukić, et al. "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study." European Journal of Internal Medicine 82 (2020): 68-75. https://doi.org/10.1016/j.ejim.2020.08.005

Mikolašević, I., et al. (2020) 'Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study', European Journal of Internal Medicine, 82, str. 68-75. doi: 10.1016/j.ejim.2020.08.005

Mikolašević I, Domislović V, Turk Wensveen T, Delija B, Klapan M, Jurić T, i sur.. Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study. European Journal of Internal Medicine [Internet]. 2020. [pristupljeno 13.04.2024.];82:68-75. doi: 10.1016/j.ejim.2020.08.005

I. Mikolašević, et al., "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study", European Journal of Internal Medicine, vol. 82, str. 68-75, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:345625. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:345625
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Podaci o radu
Naslov (engleski)Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
AutorIvana Mikolašević
AutorV Domislović
AutorTamara Turk Wensveen
AutorBožena Delija
AutorMia Klapan
AutorToni Jurić
AutorAnđela Lukić
AutorA Mijić
AutorN Skenderević
AutorP Puž
AutorA Ostojić
AutorŽ Krznarić
AutorDavor Štimac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: To investigate the prevalence and severity of nonalcoholic fatty liver disease (NAFLD) in patients with diabetes mellitus type 2 (T2DM), based on increased controlled attenuation parameter (CAP) and liver stiffness measurements obtained by transient elastography. In addition, we aimed to identify parameters that correlate with increased elastographic parameters of steatosis and fibrosis to provide a better indication when a patient with T2DM should be screened for NAFLD. Methods: We conducted prospective, cross-sectional study of 679 consecutive adult patients with diagnosed T2DM mean age 65.2±11.6. NAFLD was defined by transient elastography. In 105 patients a percutaneous liver biopsy (LB) was done. Results: The prevalence of NAFLD based on transient elastography was 83.6%. Independent factors associated with increased CAP were higher body mass index, longer T2DM duration, higher serum triglyceride, lower levels of vitamin D, higher C-reactive protein, and higher HOMA-IR. The prevalence of moderate liver fibrosis was 26.9% and advanced liver fibrosis 12.6%. Independent factors associated with moderated fibrosis based on elastography were higher body mass index and higher levels of alanine aminotransferase (ALT), while independent factors associated with advanced fibrosis were female gender, higher body mass index, higher levels of ALT, gama-glutamil transferase and C-reactive protein. Sixty-four (60.9%) of 105 patients with LB had NAFLD activity score ≥5. Regarding the presence and stages of fibrosis based on LB, moderate fibrosis was found in 29.5% of patients, while 29.5% had advanced fibrosis and 6.7% cirrhosis. Conclusion: This study supports more aggressive screening for NAFLD and fibrosis in patients with T2DM.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Internal Medicine
Brojčani podacivol. 82, str. 68-75
p-ISSN0953-6205
DOIhttps://doi.org/10.1016/j.ejim.2020.08.005
URN:NBNurn:nbn:hr:184:345625
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1107043
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-07 17:27:07