prikaz prve stranice dokumenta Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
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Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
Annals of the Rheumatic Diseases, 78 (2019), 5; 648-656. https://doi.org/10.1136/annrheumdis-2018-213455
(EUSTAR Collaboration) Wu, Wanlong; Jordan, Suzana; Graf, Nicole; de Oliveira Pena, Janethe; Curram, John; Allanore, Yannick; Matucci- Cerinic, Marco; Pope, Janet E.; Denton, Christopher P.; Khanna, Dinesh; Distler, Oliver; ...; Novak, Srđan; ...; Martinović, Duška; ...; Anić, Branimir; Barešić, Marko; Mayer, Miroslav; ... Više autora...

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Wu, W., Jordan, S., Graf, N., de Oliveira Pena, J., Curram, J., Allanore, Y. ... Mayer, M. (2019). Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort. Annals of the Rheumatic Diseases, 78. (5), 648-656. doi: 10.1136/annrheumdis-2018-213455

Wu, Wanlong, et al. "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort." Annals of the Rheumatic Diseases, vol. 78, br. 5, 2019, str. 648-656. https://doi.org/10.1136/annrheumdis-2018-213455

Wu, Wanlong, Suzana Jordan, Nicole Graf, Janethe de Oliveira Pena, John Curram, Yannick Allanore, Marco Matucci Cerinic, et al. "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort." Annals of the Rheumatic Diseases 78, br. 5 (2019): 648-656. https://doi.org/10.1136/annrheumdis-2018-213455

Wu, W., et al. (2019) 'Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort', Annals of the Rheumatic Diseases, 78(5), str. 648-656. doi: 10.1136/annrheumdis-2018-213455

Wu W, Jordan S, Graf N, de Oliveira Pena J, Curram J, Allanore Y, i sur.. Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort. Annals of the Rheumatic Diseases [Internet]. 2019. [pristupljeno 02.12.2024.];78(5):648-656. doi: 10.1136/annrheumdis-2018-213455

W. Wu, et al., "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort", Annals of the Rheumatic Diseases, vol. 78, br. 5, str. 648-656, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:498344. [Citirano: 02.12.2024.]

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Naslov (engleski)Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
AutorWanlong Wu
AutorSuzana Jordan
AutorNicole Graf
AutorJanethe de Oliveira Pena
AutorJohn Curram
AutorYannick Allanore
AutorMarco Matucci- Cerinic
AutorJanet E. Pope
AutorChristopher P. Denton
AutorDinesh Khanna
AutorOliver Distler
Autor
...
AutorSrđan Novak
Autor
...
AutorDuška Martinović
Autor
...
AutorBranimir Anić
MBZ: 140514
AutorMarko Barešić
MBZ: 224326
AutorMiroslav Mayer
MBZ: 383474
Autor
...
KolaboracijaEUSTAR Collaboration
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcssc). Methods We evaluated patients from the european scleroderma Trials and Research database with dcssc, baseline modified Rodnan skin score (mRss) ≥7, valid mRss at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRss >5 and ≥25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ≥10% (53.6% vs 34.4% ; p<0.001) and all-cause death (15.4% vs 7.3% ; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRss (≤22/51) or short disease duration (≤15 months). in multivariable analyses, skin progression within 1 year was independently associated with FVC decline ≥10% (HR 1.79, 95% Ci 1.20 to 2.65) and allcause death (HR 2.58, 95% Ci 1.31 to 5.09). Conclusions Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcssc during follow-up. These results confirm mRss as a surrogate marker in dcssc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of the Rheumatic Diseases
Brojčani podacivol. 78, br. 5, str. 648-656
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/annrheumdis-2018-213455
URN:NBNurn:nbn:hr:184:498344
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1048063
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2022-03-03 13:46:48