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Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis
Arthritis & Rheumatology, 71 (2019), 9; 1553-1570. https://doi.org/10.1002/art.40906
(EUSTAR Collaboration) Sobanski, Vincent; Giovannelli, Jonathan; ...; Novak, Srđan; ...; Martinović, Duška; ...; Morović- Vergles, Jadranka; ...; Anić, Branimir; Barešić, Marko; Mayer, Miroslav; ...; ...

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Sobanski, V., Giovannelli, J., Novak, S., Martinović, D., Morović Vergles, J., Anić, B. ... Mayer, M. (2019). Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis. Arthritis & Rheumatology, 71. (9), 1553-1570. doi: 10.1002/art.40906

Sobanski, Vincent, et al. "Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis." Arthritis & Rheumatology, vol. 71, br. 9, 2019, str. 1553-1570. https://doi.org/10.1002/art.40906

Sobanski, Vincent, Jonathan Giovannelli, Srđan Novak, Duška Martinović, Jadranka Morović Vergles, Branimir Anić, Marko Barešić i Miroslav Mayer. "Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis." Arthritis & Rheumatology 71, br. 9 (2019): 1553-1570. https://doi.org/10.1002/art.40906

Sobanski, V., et al. (2019) 'Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis', Arthritis & Rheumatology, 71(9), str. 1553-1570. doi: 10.1002/art.40906

Sobanski V, Giovannelli J, Novak S, Martinović D, Morović Vergles J, Anić B, i sur.. Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis. Arthritis & Rheumatology [Internet]. 2019. [pristupljeno 14.11.2024.];71(9):1553-1570. doi: 10.1002/art.40906

V. Sobanski, et al., "Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis", Arthritis & Rheumatology, vol. 71, br. 9, str. 1553-1570, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:759959. [Citirano: 14.11.2024.]

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Podaci o radu
Naslov (engleski)Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis
AutorVincent Sobanski
AutorJonathan Giovannelli
Autor
...
AutorSrđan Novak
Autor
...
AutorDuška Martinović
Autor
...
AutorJadranka Morović- Vergles
MBZ: 140933
Autor
...
AutorBranimir Anić
MBZ: 140514
AutorMarko Barešić
MBZ: 224326
AutorMiroslav Mayer
MBZ: 383474
Autor
...
Autor
...
KolaboracijaEUSTAR Collaboration
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVE: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. METHODS: A total of 11, 318 patients were registered in the EUSTAR database, and 6, 927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. RESULTS: Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. CONCLUSION: Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArthritis & Rheumatology
Brojčani podacivol. 71, br. 9, str. 1553-1570
p-ISSN2326-5191
DOIhttps://doi.org/10.1002/art.40906
URN:NBNurn:nbn:hr:184:759959
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1030428
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-03-02 14:12:52