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Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
Personalized medicine, 15 (2018), 3; 1-13. https://doi.org/10.2217/pme-2017-0092
Ašić, Adna; Marjanović, Damir; Mirat, Jure; Primorac, Dragan

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Ašić, A., Marjanović, D., Mirat, J. i Primorac, D. (2018). Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives. Personalized medicine, 15. (3), 1-13. doi: 10.2217/pme-2017-0092

Ašić, Adna, et al. "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives." Personalized medicine, vol. 15, br. 3, 2018, str. 1-13. https://doi.org/10.2217/pme-2017-0092

Ašić, Adna, Damir Marjanović, Jure Mirat i Dragan Primorac. "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives." Personalized medicine 15, br. 3 (2018): 1-13. https://doi.org/10.2217/pme-2017-0092

Ašić, A., et al. (2018) 'Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives', Personalized medicine, 15(3), str. 1-13. doi: 10.2217/pme-2017-0092

Ašić A, Marjanović D, Mirat J, Primorac D. Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives. Personalized medicine [Internet]. 2018. [pristupljeno 12.11.2024.];15(3):1-13. doi: 10.2217/pme-2017-0092

A. Ašić, D. Marjanović, J. Mirat i D. Primorac, "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives", Personalized medicine, vol. 15, br. 3, str. 1-13, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:403873. [Citirano: 12.11.2024.]

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Naslov (engleski)Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
AutorAdna Ašić
AutorDamir Marjanović
AutorJure Mirat
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Sažetak (engleski)
Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug–drug and food–drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected. In this review, previous findings in pharmacogenetics of dabigatran, rivaroxaban, apixaban and edoxaban are summarized, along with recommendations for studying genes encoding metabolically important enzymes for four selected NOACs. Future directions include identification of clinically relevant SNPs, and change in optimum dosage for patients who are carriers of significant variants.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPersonalized medicine
Brojčani podacivol. 15, br. 3, str. 1-13
p-ISSN1741-0541
DOIhttps://doi.org/10.2217/pme-2017-0092
URN:NBNurn:nbn:hr:184:403873
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/945582
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-02 11:07:32