prikaz prve stranice dokumenta Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
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Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
Molecular nutrition & food research, 60 (2016), 3; 530-541. https://doi.org/10.1002/mnfr.201500409
Potočnjak, Iva; Škoda, Marko; Pernjak-Pugel, Ester; Pavletić Peršić, Martina; Domitrović, Robert

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Potočnjak, I., Škoda, M., Pernjak Pugel, E., Pavletić Peršić, M. i Domitrović, R. (2016). Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. Molecular nutrition & food research, 60. (3), 530-541. doi: 10.1002/mnfr.201500409

Potočnjak, Iva, et al. "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling." Molecular nutrition & food research, vol. 60, br. 3, 2016, str. 530-541. https://doi.org/10.1002/mnfr.201500409

Potočnjak, Iva, Marko Škoda, Ester Pernjak Pugel, Martina Pavletić Peršić i Robert Domitrović. "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling." Molecular nutrition & food research 60, br. 3 (2016): 530-541. https://doi.org/10.1002/mnfr.201500409

Potočnjak, I., et al. (2016) 'Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling', Molecular nutrition & food research, 60(3), str. 530-541. doi: 10.1002/mnfr.201500409

Potočnjak I, Škoda M, Pernjak Pugel E, Pavletić Peršić M, Domitrović R. Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. Molecular nutrition & food research [Internet]. 2016. [pristupljeno 10.05.2024.];60(3):530-541. doi: 10.1002/mnfr.201500409

I. Potočnjak, M. Škoda, E. Pernjak Pugel, M. Pavletić Peršić i R. Domitrović, "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling", Molecular nutrition & food research, vol. 60, br. 3, str. 530-541, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:827156. [Citirano: 10.05.2024.]

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Naslov (engleski)Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
AutorIva Potočnjak
AutorMarko Škoda
AutorEster Pernjak-Pugel
AutorMartina Pavletić Peršić
MBZ: 247473
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Sažetak (engleski)
Oleuropein possesses numerous health beneficial effects. We investigated the renoprotective effects of oleuropein against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally gavaged with 5, 10 and 20 mg oleuropein/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, serum creatinine and blood urea nitrogen (BUN) levels were significantly elevated, with histopathological changes in renal tissue. In addition, renal oxidative stress was evidenced by increased expression of 3-nitrotyrosine (3-NT), 4-hydroxynonenal (4-HNE), cytochrome P450 E1 (CYP2E1) and heme oxygenase-1 (HO-1). The expression of nuclear factor-kappaB (NF-κB) p65, phospho-p65, tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) in the kidneys increased upon CP treatment, suggesting renal inflammation. CP intoxication increased the expression of p53, Bax and caspase-3 and induced apoptosis in the kidneys. CP administration also resulted in enhanced phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). All these effects were dose-dependently diminished by oleuropein. Oral administration of PD0325901, an MEK inhibitor, coincided with the oleuropein-mediated suppression of apoptotic, inflammatory and antioxidant markers. The results of the current study suggest that oleuropein attenuated CP-induced acute renal injury, which was mediated through the inhibition of ERK signaling.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular nutrition & food research
Brojčani podacivol. 60, br. 3, str. 530-541
p-ISSN1613-4125
DOIhttps://doi.org/10.1002/mnfr.201500409
URN:NBNurn:nbn:hr:184:827156
Datum objave publikacije2016
ProjektŠifra: 062-0000000-3554
Naziv (hrvatski): Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre
Naziv (engleski): Medical plant active compounds in the treatment of liver fibrosis
Voditelj: Robert Domitrović
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 13.06.1.2.24
Naziv (hrvatski): Intereakcija fitokemikalija i lijekova in vivo: modulacija nefrotoksičnosti cisplatina
Voditelj: Robert Domitrović
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/767421
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-03-01 14:10:33