prikaz prve stranice dokumenta Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
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Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
Food and Chemical Toxicology, 132 (2019); 1-10. https://doi.org/10.1016/j.fct.2019.110676
Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert

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Potočnjak, I., Šimić, L., Vukelić, I. i Domitrović, R. (2019). Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity. Food and Chemical Toxicology, 132., 1-10. doi: 10.1016/j.fct.2019.110676

Potočnjak, Iva, et al. "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity." Food and Chemical Toxicology, vol. 132, 2019, str. 1-10. https://doi.org/10.1016/j.fct.2019.110676

Potočnjak, Iva, Lidija Šimić, Iva Vukelić i Robert Domitrović. "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity." Food and Chemical Toxicology 132 (2019): 1-10. https://doi.org/10.1016/j.fct.2019.110676

Potočnjak, I., et al. (2019) 'Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity', Food and Chemical Toxicology, 132, str. 1-10. doi: 10.1016/j.fct.2019.110676

Potočnjak I, Šimić L, Vukelić I, Domitrović R. Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity. Food and Chemical Toxicology [Internet]. 10.2019. [pristupljeno 10.05.2024.];132:1-10. doi: 10.1016/j.fct.2019.110676

I. Potočnjak, L. Šimić, I. Vukelić i R. Domitrović, "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity", Food and Chemical Toxicology, vol. 132, str. 1-10, Listopad 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:845369. [Citirano: 10.05.2024.]

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Podaci o radu
Naslov (engleski)Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
AutorIva Potočnjak
AutorLidija Šimić
AutorIva Vukelić
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Oleanolic acid (OA) is a natural triterpenoid that possesses numerous beneficial health effects such as antioxidant, anti-inflammatory and anti-apoptotic activities. In this study, we investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP-intoxication, ameliorated the increased serum markers and histological features of kidney injury. CP administration increased renal expression of antioxidant and anti-inflammatory markers, which was reduced by OA. The increase in proapoptotic caspase-3 and -9 activations, with concomitant increase in poly (ADP-ribose) polymerase (PARP) cleavage, were dose-dependently inhibited by OA. Treatment with OA also ameliorated microtubule-associated protein 1A/1B-light chain 3B (LC3B)-II and autophagy-related protein (Atg) 5 expression induced by CP. The suppression of CP-induced oxidative stress, apoptosis, autophagy and inflammatory response by OA coincided with the inhibition of extracellular-regulated kinase (ERK) 1/2, signal transducer and activator of transcription (STAT) 3 and nuclear factor-kappa B (NF-κB). Interestingly, OA increased CP cytotoxicity in HeLa cervical cancer cells by inducing cytotoxic autophagy. The chemosensitization of HeLa cells to CP suggests a potential beneficial effect of OA in cervical cancer patients due to reduced CP dosage requirements, which requires further investigation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFood and Chemical Toxicology
Brojčani podacivol. 132, str. 1-10
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2019.110676
URN:NBNurn:nbn:hr:184:845369
Datum objave publikacije2019-10
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S027869151930465X
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-28 14:57:35