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Mercury speciation in meconium and associated factors
Environmental Research, 179 (2019); 1-9. https://doi.org/10.1016/j.envres.2019.108724
Trdin, Ajda; Falnoga, Ingrid; Fajon, Vesna; Živković, Igor; Snoj Tratnik, Janja; Prpić, Igor; Špirić, Zdravko; Horvat, Milena

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Trdin, A., Falnoga, I., Fajon, V., Živković, I., Snoj Tratnik, J., Prpić, I. ... Horvat, M. (2019). Mercury speciation in meconium and associated factors. Environmental Research, 179., 1-9. doi: 10.1016/j.envres.2019.108724

Trdin, Ajda, et al. "Mercury speciation in meconium and associated factors." Environmental Research, vol. 179, 2019, str. 1-9. https://doi.org/10.1016/j.envres.2019.108724

Trdin, Ajda, Ingrid Falnoga, Vesna Fajon, Igor Živković, Janja Snoj Tratnik, Igor Prpić, Zdravko Špirić i Milena Horvat. "Mercury speciation in meconium and associated factors." Environmental Research 179 (2019): 1-9. https://doi.org/10.1016/j.envres.2019.108724

Trdin, A., et al. (2019) 'Mercury speciation in meconium and associated factors', Environmental Research, 179, str. 1-9. doi: 10.1016/j.envres.2019.108724

Trdin A, Falnoga I, Fajon V, Živković I, Snoj Tratnik J, Prpić I, i sur.. Mercury speciation in meconium and associated factors. Environmental Research [Internet]. 2019. [pristupljeno 06.04.2025.];179:1-9. doi: 10.1016/j.envres.2019.108724

A. Trdin, et al., "Mercury speciation in meconium and associated factors", Environmental Research, vol. 179, str. 1-9, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:105348. [Citirano: 06.04.2025.]

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Naslov (engleski)Mercury speciation in meconium and associated factors
AutorAjda Trdin
AutorIngrid Falnoga
AutorVesna Fajon
AutorIgor Živković
AutorJanja Snoj Tratnik
AutorIgor Prpić
AutorZdravko Špirić
AutorMilena Horvat
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za pedijatriju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zdravstvenu ekologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Meconium is formed early in gestation and it is normally not excreted until after birth. Thus it may provide a longer and cumulative record of exposure to mercury (Hg). The present study aims to speciate Hg in meconium samples (N = 488) from Slovenian and Croatian new-borns prenatally exposed to low levels of methyl-Hg (MeHg) from maternal seafood intake and to Hg0 from maternal dental amalgam fillings. We had complete data of total Hg (THg) and MeHg in meconium and THg in maternal hair (MH),... Više while THg and MeHg in maternal blood (MB) were available only for Croatian mothers. Personal data namely maternal seafood intake, age, pre-pregnancy BMI, parity, smoking, estimated gestational age at birth, sex, and birth weight were available for the majority of participants, except the number of dental amalgams which was in most cases missing for Croatian mothers. The median THg concentration in meconium was 11.1 (range: 0.41–375.2) ng/g and inorganic Hg (Hg(II)) presented 98.8% (range: 82%–100%, CV: 2%) of THg. We observed significant correlation between meconium and MH Hg levels, with the highest correlation between hair THg and meconium MeHg. Correlation analysis including MB (available only for Croatian population) showed a significant positive correlation between THg in meconium and THg in MB (Rs = 0.642). Additionally, MeHg from MB was correlated with MeHg in meconium (Rs = 0.898), while the correlation between Hg(II) in MB and meconium was positive, but not significant. Maternal seafood intake was significantly correlated with meconium MeHg (Rs = 0.498) and Hg(II) (Rs = 0.201). Multiple linear regression (performed on the Slovenian population, N = 143) confirmed a positive association between meconium MeHg and seafood intake. Furthermore, meconium Hg(II) was positively associated with the number of maternal dental amalgam fillings, but linear regression models did not confirm correlation between seafood intake and meconium Hg(II) levels. We assume that Hg0 released from maternal dental amalgam fillings and MeHg from seafood intake were both transported through the placental barrier and portioned between different foetal compartments including meconium. Weak correlation between maternal seafood intake and Hg(II) levels in meconium suggests that there is certain evidence of MeHg demethylation. However, because this correlation was not confirmed by the multiple regression, MeHg demethylation during prenatal life cannot be neither confirmed nor excluded. Further investigations at higher level of exposure are needed to confirm this observations. We can conclude that meconium is a suitable biomarker for MeHg and Hg0 exposure during pregnancy. However, comparability of the results reported in meconium in different studies is hindered by a lack of standardized sampling protocols, storage, and analysis. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEnvironmental Research
Brojčani podacivol. 179, str. 1-9
p-ISSN0013-9351
DOIhttps://doi.org/10.1016/j.envres.2019.108724
URN:NBNurn:nbn:hr:184:105348
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1047668
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-28 09:00:58
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