prikaz prve stranice dokumenta Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats
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Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats
Transplantation proceedings, 50 (2018), 10; 3822-3830. https://doi.org/10.1016/j.transproceed.2018.08.035
Ćelić, Tanja; Omrčen, Hrvoje; Španjol, Josip; Bobinac, Dragica

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Ćelić, T., Omrčen, H., Španjol, J. i Bobinac, D. (2018). Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats. Transplantation proceedings, 50. (10), 3822-3830. doi: 10.1016/j.transproceed.2018.08.035

Ćelić, Tanja, et al. "Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats." Transplantation proceedings, vol. 50, br. 10, 2018, str. 3822-3830. https://doi.org/10.1016/j.transproceed.2018.08.035

Ćelić, Tanja, Hrvoje Omrčen, Josip Španjol i Dragica Bobinac. "Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats." Transplantation proceedings 50, br. 10 (2018): 3822-3830. https://doi.org/10.1016/j.transproceed.2018.08.035

Ćelić, T., et al. (2018) 'Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats', Transplantation proceedings, 50(10), str. 3822-3830. doi: 10.1016/j.transproceed.2018.08.035

Ćelić T, Omrčen H, Španjol J, Bobinac D. Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats. Transplantation proceedings [Internet]. 2018. [pristupljeno 14.11.2024.];50(10):3822-3830. doi: 10.1016/j.transproceed.2018.08.035

T. Ćelić, H. Omrčen, J. Španjol i D. Bobinac, "Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats", Transplantation proceedings, vol. 50, br. 10, str. 3822-3830, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:941016. [Citirano: 14.11.2024.]

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Podaci o radu
Naslov (engleski)Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats
AutorTanja Ćelić
AutorHrvoje Omrčen
AutorJosip Španjol
AutorDragica Bobinac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Deceased donor kidneys are exposed to cold ischemic insult which makes them particularly susceptible to the effects of cold ischemic injury during hypothermic preservation resulting in high rates of delayed graft function. Bone morphogenetic protein-7 (BMP-7) is a valuable reagent in the field of tissue regeneration and preservation under ischemic conditions. Following these insights, we investigated the effect of recombinant human BMP-7 (rhBMP-7) on graft preservation during cold ischemia. The study was conducted on an experimental model of kidney cold ischemia in rats. Kidneys were perfused with University of Wisconsin (UW) saline solution, rhBMP-7, or rhBMP-7 + UW, and exposed to cold ischemia for 6, 12, and 24 hours. In tubular epithelial cells of kidneys perfused with rhBMP-7 and rhBMP-7+UW solution, the expression of BMP-7 and E-cadherin was observed after 24 hours of cold ischemia. In kidneys not perfused with rhBMP-7, high expression of transforming growth factor-beta and alpha-smooth muscle actin was found. Also, in kidneys perfused with rhBMP-7 solution, statistically higher levels of Smad1, Smad5, and Smad8 messenger RNA expressions were proven. BMP-7 maintains the morphology of kidney tissue better than UW solution during 24 hours of cold ischemia. BMP-7 prevents epithelial to mesenchymal transformation and consequently maintains epithelial phenotype of tubular cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTransplantation proceedings
Brojčani podacivol. 50, br. 10, str. 3822-3830
p-ISSN0041-1345
DOIhttps://doi.org/10.1016/j.transproceed.2018.08.035
URN:NBNurn:nbn:hr:184:941016
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/984391
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-25 13:45:02