prikaz prve stranice dokumenta Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
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Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
Breast Disease, 1(2019) (2019); 1-7. https://doi.org/10.3233/bd-180341
Tomić, Snježana; Mrklić, Ivana; Razumović, Jasminka Jakić; Jonjić, Nives; Šarčević, Božena; Blažičević, Valerija; Jurković, Ilija; Vrbičić, Branka; Lisica Šikic, Nataša; Peteh, Loredana Labinac; Lončarić, Čedna Tomasović; Vučić, Majda; Gašparov, Slavko; Švagelj, Dražen; Radiković, Sandra; Mahovne, Ivana Više autora...

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Tomić, S., Mrklić, I., Razumović, J. J., Jonjić, N., Šarčević, B., Blažičević, V. ... Mahovne, I. (2019). Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,. Breast Disease, 1(2019)., 1-7. doi: 10.3233/bd-180341

Tomić, Snježana, et al. "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,." Breast Disease, vol. 1(2019), 2019, str. 1-7. https://doi.org/10.3233/bd-180341

Tomić, Snježana, Ivana Mrklić, Jasminka Jakić Razumović, Nives Jonjić, Božena Šarčević, Valerija Blažičević, Ilija Jurković, et al. "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,." Breast Disease 1(2019) (2019): 1-7. https://doi.org/10.3233/bd-180341

Tomić, S., et al. (2019) 'Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,', Breast Disease, 1(2019), str. 1-7. doi: 10.3233/bd-180341

Tomić S, Mrklić I, Razumović JJ, Jonjić N, Šarčević B, Blažičević V, i sur.. Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,. Breast Disease [Internet]. 2019. [pristupljeno 13.11.2024.];1(2019):1-7. doi: 10.3233/bd-180341

S. Tomić, et al., "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,", Breast Disease, vol. 1(2019), str. 1-7, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:344868. [Citirano: 13.11.2024.]

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Naslov (engleski)Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
Naslov (engleski)Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis
AutorSnježana Tomić
MBZ: 212900
AutorIvana Mrklić
AutorJasminka Jakić Razumović
AutorNives Jonjić
AutorBožena Šarčević
MBZ: 87995
AutorValerija Blažičević
MBZ: 232314
AutorIlija Jurković
AutorBranka Vrbičić
AutorNataša Lisica Šikic
AutorLoredana Labinac Peteh
AutorČedna Tomasović Lončarić
AutorMajda Vučić
MBZ: 251431
AutorSlavko Gašparov
MBZ: 233824
AutorDražen Švagelj
MBZ: 224894
AutorSandra Radiković
AutorIvana Mahovne
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background: Proliferation rate is a major determinant of the biologic behavior of the tumor and provides information that can be used to guide treatment decisions. Methods: This ring study included 27 pathologists from 14 Institutions, in order to assess inter-observer concordance between pathologists in Croatia. We analyzed Ki-67 proliferative index on ten randomly selected breast cancer samples comparing consistency between visual assessment using light microscopy compared to digital image analyses results from one central laboratory as a referral value. Results: When we analyzed Ki-67 as numeric value high concordance rate was found between Ki-67 score visually assessed in all participating Institutions compared to referral value assessed by digital image analysis (ICC 0.76, 95% CI 0.58-0.91), and Krippendorff's alpha was 0.79 (95% CI 0.58-1.00). Concordance was better in slides with higher Ki-67 values. When we categorized Ki-67 values according to generally accepted 20% cut-off value we noticed the lower concordance rate among participants in our study. Conclusion: Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions.
Ključne riječi (hrvatski)
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBreast Disease
Brojčani podacivol. 1(2019), str. 1-7
p-ISSN0888-6008
DOIhttps://doi.org/10.3233/bd-180341
URN:NBNurn:nbn:hr:184:344868
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1003890
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-23 16:19:06