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Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users
European Addiction Research, 24 (2018), 4; 189-200. urn:nbn:hr:184:728216
Roviš, Darko; Černelič Bizjak, Maša; Vasiljev Marchesi, Vanja; Petelin, Ana; Jenuš, Tina; Vidic, Suzana; Drevenšek, Gorazd; Jenko Pražnikar, Zala

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Roviš, D., Černelič Bizjak, M., Vasiljev Marchesi, V., Petelin, A., Jenuš, T., Vidic, S. ... Jenko Pražnikar, Z. (2018). Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users. European Addiction Research, 24. (4), 189-200. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:728216

Roviš, Darko, et al. "Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users." European Addiction Research, vol. 24, br. 4, 2018, str. 189-200. https://urn.nsk.hr/urn:nbn:hr:184:728216

Roviš, Darko, Maša Černelič Bizjak, Vanja Vasiljev Marchesi, Ana Petelin, Tina Jenuš, Suzana Vidic, Gorazd Drevenšek i Zala Jenko Pražnikar. "Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users." European Addiction Research 24, br. 4 (2018): 189-200. https://urn.nsk.hr/urn:nbn:hr:184:728216

Roviš, D., et al. (2018) 'Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users', European Addiction Research, 24(4), str. 189-200. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:728216 (Datum pristupa: 21.10.2024.)

Roviš D, Černelič Bizjak M, Vasiljev Marchesi V, Petelin A, Jenuš T, Vidic S, i sur.. Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users. European Addiction Research [Internet]. 2018. [pristupljeno 21.10.2024.];24(4):189-200. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:728216

D. Roviš, et al., "Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users", European Addiction Research, vol. 24, br. 4, str. 189-200, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:728216. [Citirano: 21.10.2024.]

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Naslov (engleski)Increased Risk-Taking Behaviour and Brain-Derived Neurotrophic Factor Val66Met Polymorphism Correlates to Decreased Serum Brain-Derived Neurotrophic Factor Level in Heroin Users
AutorDarko Roviš
AutorMaša Černelič Bizjak
AutorVanja Vasiljev Marchesi
AutorAna Petelin
AutorTina Jenuš
AutorSuzana Vidic
AutorGorazd Drevenšek
AutorZala Jenko Pražnikar
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za socijalnu medicinu i epidemiologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
Background: This study has examined the relationships and interactions between serum brain-derived neurotrophic factor (BDNF) levels, BDNF Val66Met polymorphism and self-reported risk-taking behaviour in individuals with a history of heroin use undergoing outpatient treatment in comparison to healthy individuals. Methods: We enrolled 167 heroin users and 86 healthy subjects and examined serum BDNF levels, Val66Met polymorphism, and personal characteristics using Connor Davidson Resilience Scale, Risk-taking (RT) propensity questionnaire, and Personality Assessment Inventory. Results: Heroin users had significantly higher serum BDNF levels than controls. In addition, serum BDNF levels were significantly higher in Val/Val carriers than in Met/Val or Met/Met in all recruited subjects. Furthermore, a stepwise multiple regression analysis of serum BDNF levels as a dependent variable with related factors showed that in heroin users, Alcohol Use Disorder Identification Test score, anxiety and RT score were found as independent contributors to serum BDNF levels. When performing gene-environment interaction it was additionally found that heroin users with self-reported high risk-taking behaviour had significantly lower levels of serum BDNF among heroin users with the Met allele. Conclusions: These results indicate that genetic variant Met66 decreased the serum BDNF levels in combination with self-reported risk-taking propensity among heroin users. If results of future work confirm the influence of this combined effect between neurotrophic genotype and risk-taking behaviour, 66Met carriers might require higher levels of intervention to overcome their drug use pattern and risky behaviour.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Addiction Research
Brojčani podacivol. 24, br. 4, str. 189-200
p-ISSN1022-6877
e-ISSN1421-9891
URN:NBNurn:nbn:hr:184:728216
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/951532
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-23 09:46:25