prikaz prve stranice dokumenta Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
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Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
American Journal of Reproductive Immunology, 80 (2018); 12978. https://doi.org/10.1111/aji.12978
Gulić, Tamara; Laškarin, Gordana; Dominović, Marin; Glavan Gačanin, Lana; Babarović, Emina; Rubeša, Željka; Haller, Herman; Rukavina, Daniel

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Gulić, T., Laškarin, G., Dominović, M., Glavan Gačanin, L., Babarović, E., Rubeša, Ž. ... Rukavina, D. (2018). Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American Journal of Reproductive Immunology, 80.. doi: 10.1111/aji.12978

Gulić, Tamara, et al. "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion." American Journal of Reproductive Immunology, vol. 80, 2018. https://doi.org/10.1111/aji.12978

Gulić, Tamara, Gordana Laškarin, Marin Dominović, Lana Glavan Gačanin, Emina Babarović, Željka Rubeša, Herman Haller i Daniel Rukavina. "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion." American Journal of Reproductive Immunology 80 (2018). https://doi.org/10.1111/aji.12978

Gulić, T., et al. (2018) 'Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion', American Journal of Reproductive Immunology, 80. doi: 10.1111/aji.12978

Gulić T, Laškarin G, Dominović M, Glavan Gačanin L, Babarović E, Rubeša Ž, i sur.. Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American Journal of Reproductive Immunology [Internet]. 2018. [pristupljeno 04.12.2024.];80. doi: 10.1111/aji.12978

T. Gulić, et al., "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion", American Journal of Reproductive Immunology, vol. 80, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:094317. [Citirano: 04.12.2024.]

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Naslov (engleski)Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
AutorTamara Gulić
AutorGordana Laškarin
AutorMarin Dominović
AutorLana Glavan Gačanin
AutorEmina Babarović
AutorŽeljka Rubeša
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Granulysin (GNLY) is a cytotoxic molecule mostly present in decidual natural killer (NK) cells. Blighted ovum (BO) and missed abortion (MA) represent the early pathological pregnancies with hindered development of the embryoblast or a dead embryo. We investigated the GNLY-mediated apoptotic mechanism potentially responsible for delayed termination of pregnancy. METHOD OF STUDY: We performed immunohistological and immunofluorescence labeling of decidual tissues (GNLY, Apaf-1, NF-κB). NKG2A expression was analyzed by flow cytometry and GNLY mRNA by RT- qPCR. RESULTS: The GNLY labeling intensity (H score) was lower in the nuclei of trophoblast cells in BO and MA. GNLY gene levels were inversely detected in BO and MA. A decreased decidual NK cell percentage was found in MA. NK cells from pathological pregnancies expressed lower NKG2A levels. The highest frequency of Apaf-1 was found in trophoblast cells of MA. NF- kB was highly expressed in decidual cells of BO. CONCLUSION: The reduced activation of GNLY- mediated killing might be implicated in the slower rejection of trophoblast cells in BO and MA. A decreased authentic decidual NK cell number could be responsible for low cytotoxicity against trophoblast cells in MA. In BO, trophoblast cells have a higher survival potential due to increased NF-kB expression
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 80, 12978
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/aji.12978
URN:NBNurn:nbn:hr:184:094317
Datum objave publikacije2018
ProjektŠifra: 13.06.1.1.06
Naziv (hrvatski): Imuno-endokrini mehanizmi na majčino-fetalnom spoju tijekom rane trudnoće
Voditelj: Daniel Rukavina
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1049772
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-02-22 16:30:05