prikaz prve stranice dokumenta Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
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Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
Journal of maternal-fetal & neonatal medicine, 34 (2019), 14; 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.
Barišić, Anita; Pereza, Nina; Hodžić, Alenka; Gašparović Krpina, Milena; Ostojić, Saša; Peterlin, Borut

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Barišić, A., Pereza, N., Hodžić, A., Gašparović Krpina, M., Ostojić, S. i Peterlin, B. (2019). Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss. Journal of maternal-fetal & neonatal medicine, 34. (14), 2221-2226. doi: 10.1080/14767058.2019.1660768.

Barišić, Anita, et al. "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss." Journal of maternal-fetal & neonatal medicine, vol. 34, br. 14, 2019, str. 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.

Barišić, Anita, Nina Pereza, Alenka Hodžić, Milena Gašparović Krpina, Saša Ostojić i Borut Peterlin. "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss." Journal of maternal-fetal & neonatal medicine 34, br. 14 (2019): 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.

Barišić, A., et al. (2019) 'Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss', Journal of maternal-fetal & neonatal medicine, 34(14), str. 2221-2226. doi: 10.1080/14767058.2019.1660768.

Barišić A, Pereza N, Hodžić A, Gašparović Krpina M, Ostojić S, Peterlin B. Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss. Journal of maternal-fetal & neonatal medicine [Internet]. 2019. [pristupljeno 26.12.2024.];34(14):2221-2226. doi: 10.1080/14767058.2019.1660768.

A. Barišić, N. Pereza, A. Hodžić, M. Gašparović Krpina, S. Ostojić i B. Peterlin, "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss", Journal of maternal-fetal & neonatal medicine, vol. 34, br. 14, str. 2221-2226, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:607550. [Citirano: 26.12.2024.]

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Naslov (engleski)Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
AutorAnita Barišić
AutorNina Pereza
AutorAlenka Hodžić
AutorMilena Gašparović Krpina
AutorSaša Ostojić
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Purpose: Recurrent pregnancy loss (RPL) is a reproductive disorder defined as the loss of two or more pregnancies before 24 weeks of gestation. Despite the fact that several mechanisms have been previously described for the pathogenesis of RPL, the causes of approximately 50% of cases remain unknown. However, recent studies indicate association of vitamin D deficiency with adverse pregnancy outcome, including RPL. The vitamin D receptor (VDR) is a crucial mediator of the pleiotropic cellular effects of vitamin D. Its function is influenced by several single nucleotide polymorphisms (SNPs). The main objective of the present study was to assess whether maternal VDR SNPs are associated with the risk of RPL in Slovenian and Croatian women. Methods: A case – control study including 320 women with recurrent pregnancy loss and control women was designed to examine the potential association of VDR polymorphisms (FokI rs222857, Cdx2 rs11568820 and Taq1 rs731236) with RPL. Genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism methods. Results: We found a statistically significant higher frequency of the rs222857 CC genotype (X2 = 6.61, p = 0.036) and C allele (X2 = 5.93, p = 0.015) in RPL women compared to controls. Subsequently, the odds for RPL for the rs222857 were increased under the recessive (CCvsCT + TT: OR = 1.78 ; 95% CI = 1.12–2.82 ; p = 0.015) and the codominant (CCvsTT: OR = 2.21 ; 95% CI = 1.08–4.53 ; p = 0.029 ; CCvsCT: OR = 1.68 ; 95% CI = 1.04–2.72 ; p = 0.036) genetic models. The other two analyzed polymorphisms did not show any statistical significant result. Conclusions: Our results suggest that variations in the maternal VDR FokI gene might be associated with RPL in Slovenian and Croatian women.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of maternal-fetal & neonatal medicine
Brojčani podacivol. 34, br. 14, str. 2221-2226
p-ISSN1476-7058
DOIhttps://doi.org/10.1080/14767058.2019.1660768.
URN:NBNurn:nbn:hr:184:607550
Datum objave publikacije2019
ProjektŠifra: 17.07.2.1.04
Naziv (hrvatski): Genska varijabilnost i epigenetički čimbenici u idiopatskim ponavljajućim spontanim pobačajima i spontanom prijevremenom porodu
Voditelj: Nina Pereza
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1019096
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-02-22 15:49:31