prikaz prve stranice dokumenta Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma
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Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma
Neoplasma, 67 (2020), 2; 421-429. https://doi.org/10.4149/neo_2020_190601N478.
Radolović, P.; Grebić, Damir.; Mustać, Elvira; Sebaher, I.; Mamić, J.; Miletić, W.

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Radolović, P., Grebić, D., Mustać, E., Sebaher, I., Mamić, J. i Miletić, W. (2020). Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma. Neoplasma, 67. (2), 421-429. doi: 10.4149/neo_2020_190601N478.

Radolović, P., et al. "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma." Neoplasma, vol. 67, br. 2, 2020, str. 421-429. https://doi.org/10.4149/neo_2020_190601N478.

Radolović, P., Damir. Grebić, Elvira Mustać, I. Sebaher, J. Mamić i W. Miletić. "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma." Neoplasma 67, br. 2 (2020): 421-429. https://doi.org/10.4149/neo_2020_190601N478.

Radolović, P., et al. (2020) 'Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma', Neoplasma, 67(2), str. 421-429. doi: 10.4149/neo_2020_190601N478.

Radolović P, Grebić D, Mustać E, Sebaher I, Mamić J, Miletić W. Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma. Neoplasma [Internet]. 2020. [pristupljeno 17.04.2024.];67(2):421-429. doi: 10.4149/neo_2020_190601N478.

P. Radolović, D. Grebić, E. Mustać, I. Sebaher, J. Mamić i W. Miletić, "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma", Neoplasma, vol. 67, br. 2, str. 421-429, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:682023. [Citirano: 17.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:682023
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Podaci o radu
Naslov (engleski)Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma
AutorP. Radolović
AutorDamir. Grebić
AutorElvira Mustać
AutorI. Sebaher
AutorJ. Mamić
AutorW. Miletić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Breast carcinoma shows extensive clinical and molecular heterogenicity. Glycoprotein gp96 is considered a negative prognostic and predictive factor. Controversy exists over the prognostic role of tumor lymphocytic infiltrates. The goal of this study is to illustrate differences in gp96 and CD4+ and CD8+ T-lymphocytes expression among all immunohistochemical groups of breast carcinoma in relation to the clinical course and outcome of the disease. A retrospective observational study was conducted through processing and analysis of 152 female patient tissue samples previously classified by immunohistochemistry. After immunohistochemical processing, the samples were microscopically analyzed and positive cells were manually calculated in the entire biopsy sample for each patient. In the group of patients with triple negative carcinoma, a significantly higher number of CD4 positive cells in patients with no local recurrence were proven, as well as a significant correlation between a smaller number of CD4 positive cells with a lethal outcome. In the group of patients with Luminal B HER2+ carcinoma, a significantly higher proportion of CD8+ cells in patients with local recurrence were demonstrated. The highest glycoprotein gp96 expression was demonstrated in the group of patients with triple negative carcinoma, while the lowest in patients with Luminal A and Luminal B HER2– carcinoma. This study has shown significantly higher gp96 expression and higher extent of tumor lymphocytic infiltrate in more malignant types of breast carcinoma and represents a significant contribution in affirmation of the prognostic role of these variables.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeoplasma
Brojčani podacivol. 67, br. 2, str. 421-429
e-ISSN1338-4317
DOIhttps://doi.org/10.4149/neo_2020_190601N478.
URN:NBNurn:nbn:hr:184:682023
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1056286
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-22 08:25:16