prikaz prve stranice dokumenta Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism
Rad je dostupan svim korisnicima iz sustava znanosti i visokog obrazovanja RH
Znanstveni rad - Izvorni znanstveni rad
Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism
Nature Microbiology, 5 (2019), 2; 331-342. https://doi.org/10.1038/s41564-019-0624-1
Muscolino, Elena; Schmitz, Rebekka; Loroch, Stefan; Caragliano, Enrico; Schneider, Carola; Rizzato, Matteo; Kim, Young-Hyun; Krause, Eva; Juranić Lisnić, Vanda; Sickmann, Albert; Reimer, Rudolph; Ostermann, Eleonore; Brune, Wolfram

Citirajte ovaj rad

Muscolino, E., Schmitz, R., Loroch, S., Caragliano, E., Schneider, C., Rizzato, M. ... Brune, W. (2019). Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism. Nature Microbiology, 5. (2), 331-342. doi: 10.1038/s41564-019-0624-1

Muscolino, Elena, et al. "Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism." Nature Microbiology, vol. 5, br. 2, 2019, str. 331-342. https://doi.org/10.1038/s41564-019-0624-1

Muscolino, Elena, Rebekka Schmitz, Stefan Loroch, Enrico Caragliano, Carola Schneider, Matteo Rizzato, Young Hyun Kim, et al. "Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism." Nature Microbiology 5, br. 2 (2019): 331-342. https://doi.org/10.1038/s41564-019-0624-1

Muscolino, E., et al. (2019) 'Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism', Nature Microbiology, 5(2), str. 331-342. doi: 10.1038/s41564-019-0624-1

Muscolino E, Schmitz R, Loroch S, Caragliano E, Schneider C, Rizzato M, i sur.. Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism. Nature Microbiology [Internet]. 2019. [pristupljeno 26.12.2024.];5(2):331-342. doi: 10.1038/s41564-019-0624-1

E. Muscolino, et al., "Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism", Nature Microbiology, vol. 5, br. 2, str. 331-342, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:537367. [Citirano: 26.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:537367
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism
AutorElena Muscolino
AutorRebekka Schmitz
AutorStefan Loroch
AutorEnrico Caragliano
AutorCarola Schneider
AutorMatteo Rizzato
AutorYoung-Hyun Kim
AutorEva Krause
AutorVanda Juranić Lisnić
AutorAlbert Sickmann
AutorRudolph Reimer
AutorEleonore Ostermann
AutorWolfram Brune
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viruses manipulate cellular signalling by inducing the degradation of crucial signal transducers, usually via the ubiquitin-proteasome pathway. Here, we show that the murine cytomegalovirus (Murid herpesvirus 1) M45 protein induces the degradation of two cellular signalling proteins, the nuclear factor κ-light- chain-enhancer of activated B cells (NF-κB) essential modulator (NEMO) and the receptor- interacting protein kinase 1 (RIPK1), via a different mechanism: it induces their sequestration as insoluble protein aggregates and subsequently facilitates their degradation by autophagy. Aggregation of target proteins requires a distinct sequence motif in M45, which we termed 'induced protein aggregation motif'. In a second step, M45 recruits the retromer component vacuolar protein sorting 26B (VPS26B) and the microtubule-associated protein light chain 3 (LC3)-interacting adaptor protein TBC1D5 to facilitate degradation of aggregates by selective autophagy. The induced protein aggregation motif is conserved in M45-homologous proteins of several human herpesviruses, including herpes simplex virus, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, but is only partially conserved in the human cytomegalovirus UL45 protein. We further show that the HSV-1 ICP6 protein induces RIPK1 aggregation and degradation in a similar fashion to M45. These data suggest that induced protein aggregation combined with selective autophagy of aggregates (aggrephagy) represents a conserved viral immune-evasion mechanism.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Microbiology
Brojčani podacivol. 5, br. 2, str. 331-342
e-ISSN2058-5276
DOIhttps://doi.org/10.1038/s41564-019-0624-1
URN:NBNurn:nbn:hr:184:537367
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1093304
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-22 07:36:30