prikaz prve stranice dokumenta Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
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Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
Acta Histochemica, 119 (2017), 7; 719-726. https://doi.org/10.1016/j.acthis.2017.09.003
Perić Kačarević, Željka; Grgić, Anđela; Šnajder, Darija; Bijelić, Nikola; Belovari, Tatjana; Cvijanović, Olga; Blažičević, Valerija; Radić, Radivoje

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Perić Kačarević, Ž., Grgić, A., Šnajder, D., Bijelić, N., Belovari, T., Cvijanović, O. ... Radić, R. (2017). Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring. Acta Histochemica, 119. (7), 719-726. doi: 10.1016/j.acthis.2017.09.003

Perić Kačarević, Željka, et al. "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring." Acta Histochemica, vol. 119, br. 7, 2017, str. 719-726. https://doi.org/10.1016/j.acthis.2017.09.003

Perić Kačarević, Željka, Anđela Grgić, Darija Šnajder, Nikola Bijelić, Tatjana Belovari, Olga Cvijanović, Valerija Blažičević i Radivoje Radić. "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring." Acta Histochemica 119, br. 7 (2017): 719-726. https://doi.org/10.1016/j.acthis.2017.09.003

Perić Kačarević, Ž., et al. (2017) 'Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring', Acta Histochemica, 119(7), str. 719-726. doi: 10.1016/j.acthis.2017.09.003

Perić Kačarević Ž, Grgić A, Šnajder D, Bijelić N, Belovari T, Cvijanović O, i sur.. Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring. Acta Histochemica [Internet]. 2017. [pristupljeno 13.02.2025.];119(7):719-726. doi: 10.1016/j.acthis.2017.09.003

Ž. Perić Kačarević, et al., "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring", Acta Histochemica, vol. 119, br. 7, str. 719-726, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:378578. [Citirano: 13.02.2025.]

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Podaci o radu
Naslov (engleski)Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
AutorŽeljka Perić Kačarević
MBZ: 329961
AutorAnđela Grgić
MBZ: 334740
AutorDarija Šnajder
MBZ: 310726
AutorNikola Bijelić
MBZ: 313935
AutorTatjana Belovari
MBZ: 209063
AutorOlga Cvijanović
MBZ: 269863
AutorValerija Blažičević
MBZ: 232314
AutorRadivoje Radić
MBZ: 215984
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Obesity is related to increased TNF-alpha production in different tissues. TNF-alpha is connected to mitochondrial dysfunction in the liver and also development of fatty infiltration of the liver. Also, postnatal change from normal to high-fat diet causes a significant increase in TNF-alpha serum levels. The aim of this research was to determine how maternal diet and switching male offspring to a different dietary regime after lactation influences rat liver. Ten female Sprague Dawley rats at nine weeks of age were randomly divided in two groups and fed either standard laboratory chow or high-fat diet during six weeks, and then mated with the same male subject. After birth and lactation male offspring from both groups were further divided into four subgroups depending on their subsequent diet. At 22 weeks of age, the animals were weighted, sacrificed and major organs were collected and weighted. Immunohistochemistry for TNF-alpha was performed on liver, and liver samples were analyzed for pathohistological changes. The group in which mothers were fed standard chow and offspring high-fat diet had the most pronounced changes: heaviest liver, poorest histopathological findings and strongest TNF- alpha immunohistochemical staining of liver parenchyma. High-fat diet during pregnancy and lactation and switching to high-fat diet postnatally affects liver weight, histological structure and TNF-alpha expression in male offspring.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaActa Histochemica
Brojčani podacivol. 119, br. 7, str. 719-726
p-ISSN0065-1281
DOIhttps://doi.org/10.1016/j.acthis.2017.09.003
URN:NBNurn:nbn:hr:184:378578
Datum objave publikacije2017
ProjektŠifra: 13.06.2.2.63
Naziv (hrvatski): Uloga koštanog morfogenetskog proteina - 9 u akutnom i kroničnom oštećenju jetre
Voditelj: Olga Peloza
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/893107
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2022-02-16 17:59:23