prikaz prve stranice dokumenta Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
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Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
Tropical Medicine and Infectious Disease, 5(3) (2020); 1-7. https://doi.org/10.3390/tropicalmed5030144
Vilibić-Čavlek, Tatjana; Zidovec-Lepej, Snježana; Ledina, Dragan; Knežević, Samira; Savić, Vladimir; Tabain, Irena; Ivić, Ivo; Slavuljica, Irena; Bogdanić, Maja; Grgic, Ivana; Gorenec, Lana; Stevanović, Vladimir; Barbić, Ljubo

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Vilibić Čavlek, T., Zidovec Lepej, S., Ledina, D., Knežević, S., Savić, V., Tabain, I. ... Barbić, Lj. (2020). Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases. Tropical Medicine and Infectious Disease, 5(3)., 1-7. doi: 10.3390/tropicalmed5030144

Vilibić Čavlek, Tatjana, et al. "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases." Tropical Medicine and Infectious Disease, vol. 5(3), 2020, str. 1-7. https://doi.org/10.3390/tropicalmed5030144

Vilibić Čavlek, Tatjana, Snježana Zidovec Lepej, Dragan Ledina, Samira Knežević, Vladimir Savić, Irena Tabain, Ivo Ivić, et al. "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases." Tropical Medicine and Infectious Disease 5(3) (2020): 1-7. https://doi.org/10.3390/tropicalmed5030144

Vilibić Čavlek, T., et al. (2020) 'Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases', Tropical Medicine and Infectious Disease, 5(3), str. 1-7. doi: 10.3390/tropicalmed5030144

Vilibić Čavlek T, Zidovec Lepej S, Ledina D, Knežević S, Savić V, Tabain I, i sur.. Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases. Tropical Medicine and Infectious Disease [Internet]. 2020. [pristupljeno 21.06.2024.];5(3):1-7. doi: 10.3390/tropicalmed5030144

T. Vilibić Čavlek, et al., "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases", Tropical Medicine and Infectious Disease, vol. 5(3), str. 1-7, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:142996. [Citirano: 21.06.2024.]

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Podaci o radu
Naslov (engleski)Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
AutorTatjana Vilibić-Čavlek
AutorSnježana Zidovec-Lepej
AutorDragan Ledina
AutorSamira Knežević
AutorVladimir Savić
AutorIrena Tabain
AutorIvo Ivić
AutorIrena Slavuljica
AutorMaja Bogdanić
AutorIvana Grgic
AutorLana Gorenec
AutorVladimir Stevanović
AutorLjubo Barbić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur. We report three cases of neuroinvasive TOSV infection detected in Croatia. Two patients aged 21 and 54 years presented with meningitis, while a 22-year old patient presented with meningoencephalitis and right- sided brachial plexitis. Cerebrospinal fluid (CSF), serum, and urine samples were collected and tested for neuroinvasive arboviruses: tick- borne encephalitis, West Nile, Usutu, TOSV, Tahyna, and Bhanja virus. In addition, CSF and serum samples were tested for the anti-viral cytokine response. High titers of TOSV IgM (1000–3200) and IgG (3200−10, 000) antibodies in serum samples confirmed TOSV infection. Antibodies to other phleboviruses (sandfly fever Sicilian/Naples/Cyprus virus) were negative. CSF samples showed high concentrations of interleukin 6 (IL-6 ; range 162.32−2683.90 pg/mL), interferon gamma (IFN-γ ; range 110.12−1568.07 pg/mL), and IL-10 (range 28.08−858.91 pg/mL), while significantly lower cytokine production was observed in serum. Two patients recovered fully. The patient with a brachial plexitis improved significantly at discharge. The presented cases highlight the need of increasing awareness of a TOSV as a possible cause of aseptic meningitis/ meningoencephalitis during summer months. Association of TOSV and brachial plexitis with long-term sequelae detected in one patient indicates the possibility of more severe disease, even in young patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTropical Medicine and Infectious Disease
Brojčani podacivol. 5(3), str. 1-7
e-ISSN2414-6366
DOIhttps://doi.org/10.3390/tropicalmed5030144
URN:NBNurn:nbn:hr:184:142996
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1087127
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-11 15:46:37