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Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves
Journal of Herbal Medicine, 8 (2017); 17-23. https://doi.org/10.1016/j.hermed.2017.03.006
Jurica, Karlo; Gobin, Ivana; Kremer, Dario; Vitali Čepo, Dubravka; Jurišić Grubešić, Renata; Brčić Karačonji, Irena; Kosalec, Ivan

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Jurica, K., Gobin, I., Kremer, D., Vitali Čepo, D., Jurišić Grubešić, R., Brčić Karačonji, I. i Kosalec, I. (2017). Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves. Journal of Herbal Medicine, 8., 17-23. doi: 10.1016/j.hermed.2017.03.006

Jurica, Karlo, et al. "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves." Journal of Herbal Medicine, vol. 8, 2017, str. 17-23. https://doi.org/10.1016/j.hermed.2017.03.006

Jurica, Karlo, Ivana Gobin, Dario Kremer, Dubravka Vitali Čepo, Renata Jurišić Grubešić, Irena Brčić Karačonji i Ivan Kosalec. "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves." Journal of Herbal Medicine 8 (2017): 17-23. https://doi.org/10.1016/j.hermed.2017.03.006

Jurica, K., et al. (2017) 'Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves', Journal of Herbal Medicine, 8, str. 17-23. doi: 10.1016/j.hermed.2017.03.006

Jurica K, Gobin I, Kremer D, Vitali Čepo D, Jurišić Grubešić R, Brčić Karačonji I, i sur.. Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves. Journal of Herbal Medicine [Internet]. 2017. [pristupljeno 22.10.2024.];8:17-23. doi: 10.1016/j.hermed.2017.03.006

K. Jurica, et al., "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves", Journal of Herbal Medicine, vol. 8, str. 17-23, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:154460. [Citirano: 22.10.2024.]

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Podaci o radu
Naslov (engleski)Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves
AutorKarlo Jurica
MBZ: 354371
AutorIvana Gobin
AutorDario Kremer
MBZ: 240541
AutorDubravka Vitali Čepo
MBZ: 257935
AutorRenata Jurišić Grubešić
MBZ: 225555
AutorIrena Brčić Karačonji
MBZ: 236105
AutorIvan Kosalec
MBZ: 218392
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Strawberry tree (Arbutus unedo L.) leaves are used in folk medicine for treating inflammation, hypertension, and diabetes. The aims of this study were to evaluate the antimicrobial effects of A. unedo leaf extracts on 15 uropathogens and test the extent to which arbutin, as the most abundant bioactive compound in the leaves, is responsible for their antimicrobial activity. Antimicrobial activity of leaf extracts against urinary pathogenic microorganisms was tested by agar well diffusion assay and twofolded microdilution method. Since the polyphenolic content responsible for A. unedo leaves’ antimicrobial activity depends on climate and geolocation, we determined the total phenolic, tannin, flavonoid and phenolic acid content using spectrophotometric methods, arbutin and hydroquinone mass fraction using high performance liquid chromatography coupled with a diode array detector (HPLC-DAD) and antioxidative activities by FRAP, ABTS, and DPPH assay. Although methanol was shown to be a more effective solvent for the extraction of polyphenols from leaves, water extract which could be used in clinical practice, exhibited similar antimicrobial properties. While arbutin did not show direct antimicrobial activity, its metabolite hydroquinone showed strong antimicrobial activity against the tested uropathogens. The strongest antimicrobial activity of leaf extracts was detected for uropathogenic strains of Enterococcus faecalis, which was probably associated with the ability of bacterial β-glucosidase, exerting strong activity in E. faecalis, to convert arbutin to hydroquinone. Our study suggests that strawberry tree water leaf extract has great potential as a phytotherapeutic in clinical application and should be further investigated.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Herbal Medicine
Brojčani podacivol. 8, str. 17-23
p-ISSN2210-8033
DOIhttps://doi.org/10.1016/j.hermed.2017.03.006
URN:NBNurn:nbn:hr:184:154460
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/866536
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-10 15:28:28