prikaz prve stranice dokumenta Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
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Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
Food and Chemical Toxicology, 121 (2018), -; 140-150. urn:nbn:hr:184:921774
Vukelić, Iva; Detel, Dijana; Batičić Pučar, Lara; Potočnjak, Iva; Buljević, Sunčica; Domitrović, Robert.

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Vukelić, I., Detel, D., Batičić Pučar, L., Potočnjak, I., Buljević, S. i Domitrović, R. (2018). Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food and Chemical Toxicology, 121. (-), 140-150. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, Iva, et al. "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis." Food and Chemical Toxicology, vol. 121, br. -, 2018, str. 140-150. https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, Iva, Dijana Detel, Lara Batičić Pučar, Iva Potočnjak, Sunčica Buljević i Robert. Domitrović. "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis." Food and Chemical Toxicology 121, br. - (2018): 140-150. https://urn.nsk.hr/urn:nbn:hr:184:921774

Vukelić, I., et al. (2018) 'Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis', Food and Chemical Toxicology, 121(-), str. 140-150. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:921774 (Datum pristupa: 24.10.2024.)

Vukelić I, Detel D, Batičić Pučar L, Potočnjak I, Buljević S, Domitrović R. Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food and Chemical Toxicology [Internet]. 2018. [pristupljeno 24.10.2024.];121(-):140-150. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:921774

I. Vukelić, D. Detel, L. Batičić Pučar, I. Potočnjak, S. Buljević i R. Domitrović, "Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis", Food and Chemical Toxicology, vol. 121, br. -, str. 140-150, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:921774. [Citirano: 24.10.2024.]

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Naslov (engleski)Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
AutorIva Vukelić
AutorDijana Detel
AutorLara Batičić Pučar
AutorIva Potočnjak
AutorSunčica Buljević
AutorRobert. Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Sažetak (engleski)
Chlorogenic acid (ChA) exhibits a multitude of positive health effects, however, the signaling mechanisms by which ChA could influence the inflammatory response in experimental colitis are unknown. To answer this question, we induced colitis in mice by administration of 2.5% dextran sulfate sodium (DSS) in drinking water for seven days. Oral administration of ChA significantly ameliorated clinical symptoms, improved disease activity index and colon shortening induced by DSS. Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Immunohistochemical analysis showed a dose- dependent decrease in expression and nuclear translocation of nuclear factor-kappa B (NF-κB) p65 subunit, which was accompanied by suppression of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) expression. Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase- 8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in mice administrated with ChA. The results of the current study suggest that ChA could be useful for the treatment of inflammation and attenuating colitis severity by suppressing activation of pro-inflammatory and apoptotic signaling pathways.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFood and Chemical Toxicology
Brojčani podacivol. 121, br. -, str. 140-150
p-ISSN0278-6915
URN:NBNurn:nbn:hr:184:921774
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/955144
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-10 12:43:16