prikaz prve stranice dokumenta Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
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Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
Croatian Medical Journal, 62 (2021), 4; 338-346. https://doi.org/10.3325/cmj.2021.62.338
Matas, Marijana; Sotošek, Vlatka; Kozmar, Ana; Likić, Robert; Mrak, Goran; Nagy, Bálint; Sekulić, Ante

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Matas, M., Sotošek, V., Kozmar, A., Likić, R., Mrak, G., Nagy, B. i Sekulić, A. (2021). Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. Croatian Medical Journal, 62. (4), 338-346. doi: 10.3325/cmj.2021.62.338

Matas, Marijana, et al. "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial." Croatian Medical Journal, vol. 62, br. 4, 2021, str. 338-346. https://doi.org/10.3325/cmj.2021.62.338

Matas, Marijana, Vlatka Sotošek, Ana Kozmar, Robert Likić, Goran Mrak, Bálint Nagy i Ante Sekulić. "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial." Croatian Medical Journal 62, br. 4 (2021): 338-346. https://doi.org/10.3325/cmj.2021.62.338

Matas, M., et al. (2021) 'Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial', Croatian Medical Journal, 62(4), str. 338-346. doi: 10.3325/cmj.2021.62.338

Matas M, Sotošek V, Kozmar A, Likić R, Mrak G, Nagy B, i sur.. Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. Croatian Medical Journal [Internet]. 2021. [pristupljeno 06.12.2024.];62(4):338-346. doi: 10.3325/cmj.2021.62.338

M. Matas, et al., "Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial", Croatian Medical Journal, vol. 62, br. 4, str. 338-346, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:446197. [Citirano: 06.12.2024.]

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Naslov (engleski)Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial
AutorMarijana Matas
AutorVlatka Sotošek
AutorAna Kozmar
AutorRobert Likić
AutorGoran Mrak
AutorBálint Nagy
AutorAnte Sekulić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Sažetak (engleski)
Aim To compare the effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on pro-inflammatory cytokine concentrations in patients with non-ruptured brain aneurysms undergoing elective open surgery. Methods This parallel, randomized, controlled, open-label trial was conducted at Clinical Hospital Center Zagreb between March 2019 and March 2020. At the beginning of anesthesia, lidocaine group received 40 mg of 2% lidocaine for laryngotracheal topical anesthesia and 4 mg/kg for the scalp block. Control group underwent general anesthesia only. Plasma concentrations of IL-6, TNF-α, and IL-1β were measured before anesthesia (S0); at the incision (S1); at the end of surgery (S2); 24 hours postoperatively (S3). Cerebrospinal fluid (CSF) cytokine concentrations were measured at the incision (L1) and the end of surgery (L2). Results Forty patients (each group, 20) were randomized; 37 were left in the final analysis. IL-6 plasma concentrations increased significantly compared with baseline at S3 in lidocaine group, and at S2 and S3 in control group. In both groups, changes in TNF-α and IL-1β were not significant. CSF cytokine concentrations in lidocaine group did not change significantly; in control group IL-6 and IL-1β were significantly higher at L2 than at L1. CSF IL-6 in control group significantly increased at L2, but TNF-α and IL-1β did not. No differences in clinical outcome and complication rates were observed. Conclusion Adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia might attenuate CSF IL-6 concentration increase in patients with brain aneurysm.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 62, br. 4, str. 338-346
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2021.62.338
URN:NBNurn:nbn:hr:184:446197
Datum objave publikacije2021
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491042/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-08 12:15:02