prikaz prve stranice dokumenta Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion
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Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion
Medical Hypotheses, 118 (2018); 169-173. https://doi.org/10.1016/j.mehy.2018.04.008
Laškarin, Gordana; Gulić, Tamara; Glavan Gačanin, Lana; Dominović, Marin; Haller, Herman; Rukavina, Daniel

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Laškarin, G., Gulić, T., Glavan Gačanin, L., Dominović, M., Haller, H. i Rukavina, D. (2018). Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion. Medical Hypotheses, 118., 169-173. doi: 10.1016/j.mehy.2018.04.008

Laškarin, Gordana, et al. "Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion." Medical Hypotheses, vol. 118, 2018, str. 169-173. https://doi.org/10.1016/j.mehy.2018.04.008

Laškarin, Gordana, Tamara Gulić, Lana Glavan Gačanin, Marin Dominović, Herman Haller i Daniel Rukavina. "Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion." Medical Hypotheses 118 (2018): 169-173. https://doi.org/10.1016/j.mehy.2018.04.008

Laškarin, G., et al. (2018) 'Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion', Medical Hypotheses, 118, str. 169-173. doi: 10.1016/j.mehy.2018.04.008

Laškarin G, Gulić T, Glavan Gačanin L, Dominović M, Haller H, Rukavina D. Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion. Medical Hypotheses [Internet]. 2018. [pristupljeno 13.11.2024.];118:169-173. doi: 10.1016/j.mehy.2018.04.008

G. Laškarin, T. Gulić, L. Glavan Gačanin, M. Dominović, H. Haller i D. Rukavina, "Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion", Medical Hypotheses, vol. 118, str. 169-173, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:394762. [Citirano: 13.11.2024.]

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Naslov (engleski)Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion
AutorGordana Laškarin
AutorTamara Gulić
AutorLana Glavan Gačanin
AutorMarin Dominović
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
We hypothesize that progesterone causes tolerogenic maturation of myeloid dendritic cells (DCs) in human decidua of threatened miscarriage or missed abortion characterized by a distinct phenotype and cytokine production, including reduction of the main NK cell proliferation and cytotoxic factor interleukin (IL)-15. During DC/NK cell interaction, progesterone-shaped DCs cannot efficiently multiply or equip NK cells with the cytotoxic mediators peforin and granulysin, which might harm trophoblasts and induce abortion. We propose that the presence, and maturation stage of decidual myeloid DCs be investigated using semi-quantitative immunohistological analyses and/or double-color immuno-fluorescent labeling of DC lineage and activation markers. The spatial arrangement of granulysin+ cells, NKp46+ NK cells, DCs, and trophoblasts might provide information about their mutual interactions in vivo. Multiple flow cytometry analyses of NK-receptors would provide insight into NK cell activation status. NK cell activation status could be also assessed by cytotoxicity assays against trophoblast cell lines, or isolated cognate extra-villous trophoblast cells. A correlation between decidual progesterone concentration or IL-15 expression, and the degree of DC maturation or the frequency of granulysin+ cells, might help to elucidate the mechanism of abortion retention in utero.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Hypotheses
Brojčani podacivol. 118, str. 169-173
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2018.04.008
URN:NBNurn:nbn:hr:184:394762
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/949478
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-08 11:35:23