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Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss
Psychiatria Danubina, 33 (2021), 4; 719-731. urn:nbn:hr:184:612607
Ružić Baršić, Antonija; Gudelj, Lea; Antulov, Ronald; Miletić, Damir; Knežević, Koraljka; Rubeša, Gordana

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Ružić Baršić, A., Gudelj, L., Antulov, R., Miletić, D., Knežević, K. i Rubeša, G. (2021). Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss. Psychiatria Danubina, 33. (4), 719-731. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, Antonija, et al. "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss." Psychiatria Danubina, vol. 33, br. 4, 2021, str. 719-731. https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, Antonija, Lea Gudelj, Ronald Antulov, Damir Miletić, Koraljka Knežević i Gordana Rubeša. "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss." Psychiatria Danubina 33, br. 4 (2021): 719-731. https://urn.nsk.hr/urn:nbn:hr:184:612607

Ružić Baršić, A., et al. (2021) 'Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss', Psychiatria Danubina, 33(4), str. 719-731. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:612607 (Datum pristupa: 22.10.2024.)

Ružić Baršić A, Gudelj L, Antulov R, Miletić D, Knežević K, Rubeša G. Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss. Psychiatria Danubina [Internet]. 2021. [pristupljeno 22.10.2024.];33(4):719-731. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:612607

A. Ružić Baršić, L. Gudelj, R. Antulov, D. Miletić, K. Knežević i G. Rubeša, "Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss", Psychiatria Danubina, vol. 33, br. 4, str. 719-731, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:612607. [Citirano: 22.10.2024.]

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Podaci o radu
Naslov (engleski)Onset of Schizophrenia Prior to the End of Brain Maturation Alters Grey Matter Volume Loss
AutorAntonija Ružić Baršić
AutorLea Gudelj
MBZ: 163231
AutorRonald Antulov
MBZ: 269975
AutorDamir Miletić
AutorKoraljka Knežević
AutorGordana Rubeša
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za psihijatriju i psihološku medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za radiologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Radiologija
Sažetak (engleski)
Background: Brain maturation is considered completed around the age of 25, when prefrontal cortex maturation has been achieved. The aim of our study was to investigate the alterations of grey matter (GM) in patients with the onset of schizophrenia before and after the completion of brain maturation. Subjects and methods: The study group included 100 schizophrenia patients, while the control group comprised 50 healthy individuals. Brain magnetic resonance imaging was acquired on a 1.5 T scanner. Voxel-based morphometry (VBM) analyses were performed between groups. Results: GM of the schizophrenic patients is reduced in many regions (p<0.005 FDR corrected). Most widespread reduction is detected in frontal cortex and cerebellum, the other regions being limbic cortex, insula, cuneus, precuneus, superior temporal gyrus and motor cortex. The decrease of grey matter volume (GMV) increases with the increase in number of psychotic episodes and is more pronounced in the patients with earlier onset of the disease. Conclusions: The age of the onset of the disease is important for both total and relative loss of GMV. Earlier onset of schizophrenia, prior to full brain maturation results in significant reduction of GM in comparison with healthy subjects and patients with later, post full brain maturation onset of the disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPsychiatria Danubina
Brojčani podacivol. 33, br. 4, str. 719-731
p-ISSN0353-5053
URN:NBNurn:nbn:hr:184:612607
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1154794
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-27 15:20:39