prikaz prve stranice dokumenta MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
Cellular & Molecular Immunology, 7 (2022); 1-11. https://doi.org/10.1038/s41423-021-00814-5
Kim, Yeonsu; Zheng, Xiaoyan; Eschke, Kathrin; Chaudhry, M. Zeeshan; Bertoglio, Federico; Tomić, Adriana; Krmpotić, Astrid; Hoffmann, Markus; Bar-On, Yotam; Boehme, Julia D.; Bruder, Dunja; Ebensen, Thomas; Brunotte, Linda; Ludwig, Stephan; Messerle, Martin; Guzman, Carlos; Mandelboim, Ofer; Hust, Michael; Pöhlmann, Stefan; Jonjić, Stipan; Čičin-Šain, Luka Više autora...

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Kim, Y., Zheng, X., Eschke, K., Chaudhry, M. Z., Bertoglio, F., Tomić, A. ... Čičin Šain, L. (2022). MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular & Molecular Immunology, 7., 1-11. doi: 10.1038/s41423-021-00814-5

Kim, Yeonsu, et al. "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination." Cellular & Molecular Immunology, vol. 7, 2022, str. 1-11. https://doi.org/10.1038/s41423-021-00814-5

Kim, Yeonsu, Xiaoyan Zheng, Kathrin Eschke, M. Zeeshan Chaudhry, Federico Bertoglio, Adriana Tomić, Astrid Krmpotić, et al. "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination." Cellular & Molecular Immunology 7 (2022): 1-11. https://doi.org/10.1038/s41423-021-00814-5

Kim, Y., et al. (2022) 'MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination', Cellular & Molecular Immunology, 7, str. 1-11. doi: 10.1038/s41423-021-00814-5

Kim Y, Zheng X, Eschke K, Chaudhry MZ, Bertoglio F, Tomić A, i sur.. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular & Molecular Immunology [Internet]. 07.01.2022. [pristupljeno 05.05.2024.];7:1-11. doi: 10.1038/s41423-021-00814-5

Y. Kim, et al., "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination", Cellular & Molecular Immunology, vol. 7, str. 1-11, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:858092. [Citirano: 05.05.2024.]

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Naslov (engleski)MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
AutorYeonsu Kim
AutorXiaoyan Zheng
AutorKathrin Eschke
AutorM. Zeeshan Chaudhry
AutorFederico Bertoglio
AutorAdriana Tomić
AutorAstrid Krmpotić
AutorMarkus Hoffmann
AutorYotam Bar-On
AutorJulia D. Boehme
AutorDunja Bruder
AutorThomas Ebensen
AutorLinda Brunotte
AutorStephan Ludwig
AutorMartin Messerle
AutorCarlos Guzman
AutorOfer Mandelboim
AutorMichael Hust
AutorStefan Pöhlmann
AutorStipan Jonjić
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Abstract Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There remains a medical need for vaccines against these pathogens. CMV (cytomegalovirus) is a β-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8 T cells are maintained for a lifetime. Hence, CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous pathogens. We generated two recombinant murine CMV (MCMV) vaccine vectors expressing hemagglutinin (HA) of influenza A virus (MCMV ) or the spike protein of severe acute respiratory syndrome coronavirus 2 (MCMV ). A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses, which strengthened over time. Importantly, MCMV -vaccinated mice were protected from illness following challenge with the influenza virus, and we excluded that this protection was due to the effects of memory T cells. Conclusively, we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCellular & Molecular Immunology
Brojčani podacivol. 7, str. 1-11
p-ISSN1672-7681
e-ISSN2042-0226
DOIhttps://doi.org/10.1038/s41423-021-00814-5
URN:NBNurn:nbn:hr:184:858092
Datum objave elektroničkog izdanja2022-01-07
URL dokumentahttps://www.nature.com/articles/s41423-021-00814-5
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-26 11:32:46