Percutaneous coronary intervention (PCI) is the first choice for the diagnosis of coronary artery disease and revascularization of significant lesions in all forms in which coronary artery disease presents. Since today, the ischemic heart disease (IHD) is still the main cause of mortality in developed countries, and also in Croatia, and that the number of PCI procedures is in constant increase, both patients and professionals have the same interest of choosing the best and most appropriate way of percutaneous approach. Because of the relative simplicity of the procedure, the low percentage of complications, and a short time to mobilization after the procedure, the radial approach has become dominant over femoral approach, although patients have to be aware of the possible limitations and risks of both of the methods. Before making any decision, it is necessary to assess potential risks and benefits of the planned interventions and to compare them to alternative treatments such as medical or surgical. Today's indications for PCI are very broad and include patient range from asymptomatic to unstable, with varying degrees of myocardial jeopardy. In the process, the appropriate patients are selected, the location of the arteries of the handis determined (because of the possible anatomic variations) and whether they are viable (Allen test), which is an essential condition for the implementation of the procedure. Because of the high risk of complications (vasospasm, thrombosis ...), extra medications shoud be applied, most in the form of antiplatelet and anticoagulant therapy. Interventional cardiology is one of the fastest growing areas oftoday's medical science, and technological and pharmacological discoveries within the area, only a few years back, have led to significant changes in the treatment and prognosis of patients with cardiovascular disease.