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The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding
Pathogens, 10 (2021), 7; 866. https://doi.org/10.3390/pathogens10070866
Chan, Baca; Arapović, Maja; Masters, Laura L.; Rwandamuiye, Francois; Jonjić, Stipan; Smith, Lee M.; Redwood, Alec J.

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Chan, B., Arapović, M., Masters, L. L., Rwandamuiye, F., Jonjić, S., Smith, L. M. i Redwood, A. J. (2021). The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding. Pathogens, 10. (7). doi: 10.3390/pathogens10070866

Chan, Baca, et al. "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding." Pathogens, vol. 10, br. 7, 2021. https://doi.org/10.3390/pathogens10070866

Chan, Baca, Maja Arapović, Laura L. Masters, Francois Rwandamuiye, Stipan Jonjić, Lee M. Smith i Alec J. Redwood. "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding." Pathogens 10, br. 7 (2021). https://doi.org/10.3390/pathogens10070866

Chan, B., et al. (2021) 'The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding', Pathogens, 10(7). doi: 10.3390/pathogens10070866

Chan B, Arapović M, Masters LL, Rwandamuiye F, Jonjić S, Smith LM, i sur.. The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding. Pathogens [Internet]. 09.07.2021. [pristupljeno 26.12.2024.];10(7). doi: 10.3390/pathogens10070866

B. Chan, et al., "The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding", Pathogens, vol. 10, br. 7, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:426058. [Citirano: 26.12.2024.]

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Naslov (engleski)The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding
AutorBaca Chan
AutorMaja Arapović
AutorLaura L. Masters
AutorFrancois Rwandamuiye
AutorStipan Jonjić
AutorLee M. Smith
AutorAlec J. Redwood
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
As the largest herpesviruses, the 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding of host immunity and viral escape mechanisms, although many of the annotated genes remain as yet uncharacterised. Here we identify the m15 locus of murine CMV (MCMV) as a viral modulator of natural killer (NK) cell immunity. We show that, rather than discrete transcripts from the m14, m15 and m16 genes as annotated, there are five 3′-coterminal transcripts expressed over this region, all utilising a consensus polyA tail at the end of the m16 gene. Functional inactivation of any one of these genes had no measurable impact on viral replication. However, disruption of all five transcripts led to significantly attenuated dissemination to, and replication in, the salivary glands of multiple strains of mice, but normal growth during acute infection. Disruption of the m15 locus was associated with heightened NK cell responses, including enhanced proliferation and IFNγ production. Depletion of NK cells, but not T cells, rescued salivary gland replication and viral shedding. These data demonstrate the identification of multiple transcripts expressed by a single locus which modulate, perhaps in a concerted fashion, the function of anti-viral NK cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 10, br. 7, 866
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens10070866
URN:NBNurn:nbn:hr:184:426058
Datum objave publikacije2021-07-09
URL dokumentahttps://www.mdpi.com/2076-0817/10/7/866
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-09-17 12:22:23