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An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
GERMS, 11 (2021), 2; 199-210. https://doi.org/10.18683/germs.2021.1257
Matovina, Mihaela; Abram, Maja; Repac-Antić, Davorka; Knežević, Samira; Bubonja-Šonje, Marina

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Matovina, M., Abram, M., Repac Antić, D., Knežević, S. i Bubonja Šonje, M. (2021). An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex. GERMS, 11. (2), 199-210. doi: 10.18683/germs.2021.1257

Matovina, Mihaela, et al. "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex." GERMS, vol. 11, br. 2, 2021, str. 199-210. https://doi.org/10.18683/germs.2021.1257

Matovina, Mihaela, Maja Abram, Davorka Repac Antić, Samira Knežević i Marina Bubonja Šonje. "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex." GERMS 11, br. 2 (2021): 199-210. https://doi.org/10.18683/germs.2021.1257

Matovina, M., et al. (2021) 'An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex', GERMS, 11(2), str. 199-210. doi: 10.18683/germs.2021.1257

Matovina M, Abram M, Repac Antić D, Knežević S, Bubonja Šonje M. An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex. GERMS [Internet]. 2021. [pristupljeno 31.12.2024.];11(2):199-210. doi: 10.18683/germs.2021.1257

M. Matovina, M. Abram, D. Repac Antić, S. Knežević i M. Bubonja Šonje, "An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex", GERMS, vol. 11, br. 2, str. 199-210, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:844971. [Citirano: 31.12.2024.]

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Naslov (engleski)An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
AutorMihaela Matovina
MBZ: 254976
AutorMaja Abram
AutorDavorka Repac-Antić
AutorSamira Knežević
AutorMarina Bubonja-Šonje
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Introduction: Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen with dynamic molecular epidemiology. This study presents a retrospective analysis of the distribution and antibiotic resistance patterns of ertapenem-resistant ESBL-producing K. pneumoniae strains recovered during an outbreak from 2012 to 2014 in a Croatian University hospital. Methods We aimed to estimate genetic relatedness of clinical isolates and underlying mechanisms that conferred the ertapenem- resistant phenotype. Results: Expression analysis of genes involved in the antibiotic resistance showed reduced expression of major non-selective porin channel OmpK35. Reduced expression of OmpK36 porin channel in isolates resistant to at least one more carbapenem, apart from the ertapenem, was found to a lesser degree. Pulsed-field gel electrophoresis analysis of genomic DNA revealed that almost all isolates belonged to the same genetic clone. Conclusions: Caution regarding ertapenem- resistant, carbapenemase-negative porin- deficient mutants of K. pneumoniae is required as they are widespread, and under selective pressure this could result in a local clonal outbreak.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGERMS
Brojčani podacivol. 11, br. 2, str. 199-210
p-ISSN2248-2997
DOIhttps://doi.org/10.18683/germs.2021.1257
URN:NBNurn:nbn:hr:184:844971
Datum objave publikacije2021
ProjektŠifra: uniri-biomed-18-215
Naziv (hrvatski): Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B
Naziv (engleski): Prevalence and clinical significance of hepatitis B surface antigen mutants
Voditelj: Marina Bubonja Šonje
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: uniri-biomed-18-277
Naziv (hrvatski): Bakterijska patogeneza - od istraživanja do kliničke primjene
Naziv (engleski): Bacterial pathogenesis – from research to clinics
Voditelj: Maja Abram
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1139517
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-09-08 11:29:50