Parkinson's disease is the second most common neurodegenrative disease. The most common symptoms of patients with Parkinson's disease are rest tremor, rigidity, bradykinesia and gait disorder. The treatment of Parkinson's disease is very complex. The reason for this is disease's complexity and yearly progression. It can be medicamentous therapy or invasive methods like applying deep brain stimulation (DBS). There are three categories of medicamentous therapy that are used. The first category of drugs increases the level of dopamine in the brain, the second category of drugs reduces the symptoms of Parkinson's disease, such as anticholinergic drugs and the third category of drugs is used for non-motor symptoms of Parkinson's disease. If medicamentous therapy is not sufficient, deep brain stimulation is used today. Deep brain stimulation is the neurosurgical procedure involving the placement an electrode into the area of the subthalamic nucleus, ventral intermediate nucleus (VIM) in thalamus or globus pallidus because the motor complications of Parkinson's disease can not be adequately eliminated with drugs. Before the neurosurgical procedure, the preoperative preparation and evaluation of the patients, who are potential candidates for this procedure, is very important. A complete medical evaluation is necessary for the preoperative preparation of patients. The preoperative preparation and evaluation of patients should involve a multidisciplinary team of experts including psychologists, psychiatrists, neurosurgeons, with a special role for clinicians, neurologists, who know their patients best and can evaluate the patients' further quality of life after DBS is installed.