prikaz prve stranice dokumenta The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
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The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
PLOS Pathogens, 12 (2016), 12; e1006057. https://doi.org/10.1371/journal.ppat.1006057
Thiel, Nadine; Keyser, Kirsten A.; Lemmermann, Niels A. W.; Oduro, Jennifer D.; Wagner, Karen; Elsner, Carina; Halenius, Anne; Lenac Roviš, Tihana; Brinkmann, Melanie M.; Jonjić, Stipan; Čičin-Šain, Luka; Messerle, Martin

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Thiel, N., Keyser, K. A., Lemmermann, N. A. W., Oduro, J. D., Wagner, K., Elsner, C. ... Messerle, M. (2016). The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages. PLOS Pathogens, 12. (12). doi: 10.1371/journal.ppat.1006057

Thiel, Nadine, et al. "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages." PLOS Pathogens, vol. 12, br. 12, 2016. https://doi.org/10.1371/journal.ppat.1006057

Thiel, Nadine, Kirsten A. Keyser, Niels A. W. Lemmermann, Jennifer D. Oduro, Karen Wagner, Carina Elsner, Anne Halenius, et al. "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages." PLOS Pathogens 12, br. 12 (2016). https://doi.org/10.1371/journal.ppat.1006057

Thiel, N., et al. (2016) 'The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages', PLOS Pathogens, 12(12). doi: 10.1371/journal.ppat.1006057

Thiel N, Keyser KA, Lemmermann NAW, Oduro JD, Wagner K, Elsner C, i sur.. The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages. PLOS Pathogens [Internet]. 12.2016. [pristupljeno 17.11.2024.];12(12). doi: 10.1371/journal.ppat.1006057

N. Thiel, et al., "The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages", PLOS Pathogens, vol. 12, br. 12, Prosinac 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:971179. [Citirano: 17.11.2024.]

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Naslov (engleski)The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
AutorNadine Thiel
AutorKirsten A. Keyser
AutorNiels A. W. Lemmermann
AutorJennifer D. Oduro
AutorKaren Wagner
AutorCarina Elsner
AutorAnne Halenius
AutorTihana Lenac Roviš
AutorMelanie M. Brinkmann
AutorStipan Jonjić
AutorLuka Čičin-Šain
AutorMartin Messerle
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus (HCMV) is a tenacious pathogen, which can be life-threatening for immunocompromised patients and immunologically immature newborns. The pathogenicity of HCMV is owed to a plethora of immunomodulatory functions that interfere with host defense mechanisms. Such viral functions can teach us about viral pathogenesis mechanisms, and also about the functioning of immune cells. In this study we report that the mouse cytomegalovirus (MCMV)–a close relative of HCMV–influences surface expression of the cellular protein CD45 on macrophages and we identified the viral gene m42 mediating this effect. CD45 has long been known to be essential for the functioning of lymphocytes, however, its role in macrophages is less well understood. Growth analysis of a viral mutant indicated that the m42 gene confers a replication advantage to MCMV in vivo. We found that the m42 protein induces internalization of CD45 from the plasma membrane and degradation in lysosomes—most likely triggered by interaction of m42 with a ubiquitin ligase. In our study we detected a new element in the complex interaction of cytomegaloviruses with host cells, and further investigation into this mechanism may provide us with new insights into the functions of CD45 in myeloid cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 12, br. 12, e1006057
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006057
URN:NBNurn:nbn:hr:184:971179
Datum objave publikacije2016-12
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 260934
Naziv (engleski): Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection
Kratica: CMVAGSTIMULUS
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttps://dx.plos.org/10.1371/journal.ppat.1006057
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2021-01-20 18:31:23