Since alexithymia and the health locus of control are constructs with individual health effects, the main goal of this study was to examine their association. The specific objectives were to examine the relationship between the degree of alexithymia and anxiety/depression, to investigate the degree of sympathetic activation, and to determine objective predictors of alexithymia. The research was conducted at the Clinics for Psychiatry and Internal Medicine of the University Hospital Center Rijeka on a sample of 100 subjects, divided into two groups: patients with anxiety and patients with psychosomatic disorders. The following instruments were used: Sociodemographic Survey, Toronto Alexithymia Scale - 26, Hopkins - 25 Symptom Scale, and Questionnaire to Examine Perceived Source of Health Control. A manual blood pressure monitor and stethoscope were used for blood pressure measurement, the heart rate was measured with a pulse oximeter, and the respiratory rate by direct observation of the researcher. Consistent with the objectives, there was a statistically significant positive association between alexithymia, the external locus of health control, anxiety and depression. Individuals with a higher degree of alexithymia showed a preserved autonomic emotional response. It was found that lower education, higher levels of depression/anxiety and the presence of a more pronounced external locus of health control are objective indicators of alexithymia. Since alexithymia affects the ability of coping with health problems, it is important to identify patients with its characteristics, to provide them with (therapeutic) support in order to achieve the most favorable treatment outcomes and quality of life.