prikaz prve stranice dokumenta Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
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Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
Diagnostic Pathology, 6 (2011), 1; 108. https://doi.org/10.1186/1746-1596-6-108
Dekanić, Andrea; Dobrila Dintinjan, Renata; Budisavljević, Ivana; Pećanić, Sanja; Žuvić Butorac, Marta; Jonjić, Nives

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Dekanić, A., Dobrila Dintinjan, R., Budisavljević, I., Pećanić, S., Žuvić Butorac, M. i Jonjić, N. (2011). Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology, 6. (1). doi: 10.1186/1746-1596-6-108

Dekanić, Andrea, et al. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology, vol. 6, br. 1, 2011. https://doi.org/10.1186/1746-1596-6-108

Dekanić, Andrea, Renata Dobrila Dintinjan, Ivana Budisavljević, Sanja Pećanić, Marta Žuvić Butorac i Nives Jonjić. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology 6, br. 1 (2011). https://doi.org/10.1186/1746-1596-6-108

Dekanić, A., et al. (2011) 'Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification', Diagnostic Pathology, 6(1). doi: 10.1186/1746-1596-6-108

Dekanić A, Dobrila Dintinjan R, Budisavljević I, Pećanić S, Žuvić Butorac M, Jonjić N. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology [Internet]. 2011. [pristupljeno 04.12.2024.];6(1). doi: 10.1186/1746-1596-6-108

A. Dekanić, R. Dobrila Dintinjan, I. Budisavljević, S. Pećanić, M. Žuvić Butorac i N. Jonjić, "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification", Diagnostic Pathology, vol. 6, br. 1, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:036056. [Citirano: 04.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:036056
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Podaci o radu
Naslov (engleski)Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
AutorAndrea Dekanić
AutorRenata Dobrila Dintinjan
AutorIvana Budisavljević
AutorSanja Pećanić
AutorMarta Žuvić Butorac
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Background: Prognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status of tumor cells. Methods: Immunohistochemical and FISH analysis was performed on 135 archival formalin fixed and paraffin embedded CRCs. Results: Strong membrane and strong nuclear EGFR staining was detected in 16% and 57% of cases, respectively, and strong cyclin-D1 expression in 57% samples. Gene EGFR amplification was identified in 5.9% and polysomy in 7.4% of cases, while 87% showed no EGFR gene changes. A statistically significant difference was only found between tumor grade and expression of membrane EGFR, while nuclear EGFR and cyclin-D1 expression was not associated with the clinicopathologic characteristics analyzed. Tumor cells displaying gene amplification and strong protein membrane EGFR expression overlapped, while EGFR gene status showed no correlation with nuclear EGFR and cyclin-D1. There was no association between membrane EGFR and cyclin-D1, whereas nuclear EGFR expression was strongly related to cyclin-D1 expression. Conclusions: Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostic Pathology
Brojčani podacivol. 6, br. 1, 108
p-ISSN1746-1596
DOIhttps://doi.org/10.1186/1746-1596-6-108
URN:NBNurn:nbn:hr:184:036056
Datum objave publikacije2011
ProjektŠifra: 062-0620095-0082
Naziv (hrvatski): REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA
Voditelj: Nives Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-6-108
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-11-17 23:38:25