prikaz prve stranice dokumenta Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
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Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
Microorganisms, 8 (2020), 10; 1531. https://doi.org/10.3390/microorganisms8101531
Kelava, Ina; Mihelčić, Mirna; Ožanič, Mateja; Marečić, Valentina; Knežević, Maša; Ćurlin, Marija; Štifter, Sanja; Sjöstedt, Anders; Šantić, Marina

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Kelava, I., Mihelčić, M., Ožanič, M., Marečić, V., Knežević, M., Ćurlin, M. ... Šantić, M. (2020). Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs. Microorganisms, 8. (10). doi: 10.3390/microorganisms8101531

Kelava, Ina, et al. "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs." Microorganisms, vol. 8, br. 10, 2020. https://doi.org/10.3390/microorganisms8101531

Kelava, Ina, Mirna Mihelčić, Mateja Ožanič, Valentina Marečić, Maša Knežević, Marija Ćurlin, Sanja Štifter, Anders Sjöstedt i Marina Šantić. "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs." Microorganisms 8, br. 10 (2020). https://doi.org/10.3390/microorganisms8101531

Kelava, I., et al. (2020) 'Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs', Microorganisms, 8(10). doi: 10.3390/microorganisms8101531

Kelava I, Mihelčić M, Ožanič M, Marečić V, Knežević M, Ćurlin M, i sur.. Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs. Microorganisms [Internet]. 06.10.2020. [pristupljeno 22.10.2024.];8(10). doi: 10.3390/microorganisms8101531

I. Kelava, et al., "Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs", Microorganisms, vol. 8, br. 10, Listopad 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:669989. [Citirano: 22.10.2024.]

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Naslov (engleski)Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
AutorIna Kelava
AutorMirna Mihelčić
AutorMateja Ožanič
AutorValentina Marečić
AutorMaša Knežević
AutorMarija Ćurlin
AutorSanja Štifter
AutorAnders Sjöstedt
AutorMarina Šantić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Francisella tularensis is a highly virulent intracellular pathogen that proliferates within various cell types and can infect a multitude of animal species. Francisella escapes the phagosome rapidly after infection and reaches the host cell cytosol where bacteria undergo extensive replication. Once cytosolic, Francisella becomes a target of an autophagy-mediated process. The mechanisms by which autophagy plays a role in replication of this cytosolic pathogen have not been fully elucidated. In vitro, F. tularensis avoids degradation via autophagy and the autophagy process provides nutrients that support its intracellular replication, but the role of autophagy in vivo is unknown. Here, we investigated the role of autophagy in the pathogenesis of tularemia by using transgenic mice deficient in Atg5 in the myeloid lineage. The infection of Atg5-deficient mice with Francisella tularensis subsp. holarctica live vaccine strain (LVS) resulted in increased survival, significantly reduced bacterial burden in the mouse organs, and less severe histopathological changes in the spleen, liver and lung tissues. The data highlight the contribution of Atg5 in the pathogenesis of tularemia in vivo.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicroorganisms
Brojčani podacivol. 8, br. 10, 1531
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms8101531
URN:NBNurn:nbn:hr:184:669989
Datum objave publikacije2020-10-06
ProjektŠifra: IP-2016-06-9003
Naziv (hrvatski): Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije
Kratica: FRANCYCLE
Voditelj: Marina Šantić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2076-2607/8/10/1531
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-10-12 22:14:06