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COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?
American Journal of Physiology-Heart and Circulatory Physiology, 319 (2020), 4; H793-H796. https://doi.org/10.1152/ajpheart.00506.2020
Jakovac, Hrvoje

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Jakovac, H. (2020). COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?. American Journal of Physiology-Heart and Circulatory Physiology, 319. (4), H793-H796. doi: 10.1152/ajpheart.00506.2020

Jakovac, Hrvoje. "COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?." American Journal of Physiology-Heart and Circulatory Physiology, vol. 319, br. 4, 2020, str. H793-H796. https://doi.org/10.1152/ajpheart.00506.2020

Jakovac, Hrvoje. "COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?." American Journal of Physiology-Heart and Circulatory Physiology 319, br. 4 (2020): H793-H796. https://doi.org/10.1152/ajpheart.00506.2020

Jakovac, H. (2020) 'COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?', American Journal of Physiology-Heart and Circulatory Physiology, 319(4), str. H793-H796. doi: 10.1152/ajpheart.00506.2020

Jakovac H. COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?. American Journal of Physiology-Heart and Circulatory Physiology [Internet]. 01.10.2020. [pristupljeno 05.11.2024.];319(4):H793-H796. doi: 10.1152/ajpheart.00506.2020

H. Jakovac, "COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?", American Journal of Physiology-Heart and Circulatory Physiology, vol. 319, br. 4, str. H793-H796, Listopad 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:933914. [Citirano: 05.11.2024.]

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Naslov (engleski)COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?
AutorHrvoje Jakovac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
The 60-kDa heat shock protein (HSP60) is a chaperone essential for mitochondrial proteostasis ensuring thus sufficient aerobic energy production. In pathological conditions, HSP60 can be translocated from the mitochondria and excreted from the cell. In turn, the extracellular HSP60 has a strong ability to trigger and enhance inflammatory response with marked proinflammatory cytokine induction, which is mainly mediated by Toll-like receptor binding. Previous studies have found increased circulating levels of HSP60 in hypertensive patients, as well as enhanced HSP60 expression and membrane translocation in the hypertrophic myocardium. These observations are of particular interest, since they could provide a possible pathophysiological explanation of the severe course and worse outcome of severe acute respiratory syndrome coronavirus 2 infection in hypertensive patients, repeatedly reported during the recent coronavirus disease 2019 (COVID-19) pandemic and related to hyperinflammatory response and cytokine storm development during the third phase of the disease. In this regard, pharmacological inhibition of HSP60 could attract attention to potentially ameliorate inappropriate inflammatory reaction in severe COVID-19 patients. Among HSP60 antagonizing drugs, mizoribine is the most intriguing, since it is clinically approved and exerts antiviral activity. However, this topic requires to be further scrutinized.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Physiology-Heart and Circulatory Physiology
Brojčani podacivol. 319, br. 4, str. H793-H796
p-ISSN0363-6135
e-ISSN1522-1539
DOIhttps://doi.org/10.1152/ajpheart.00506.2020
URN:NBNurn:nbn:hr:184:933914
Datum objave publikacije2020-10-01
URL dokumentahttps://journals.physiology.org/doi/10.1152/ajpheart.00506.2020
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-09-28 16:18:06