prikaz prve stranice dokumenta Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
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Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
Proceedings of the National Academy of Sciences, 117 (2020), 23; 12961-12968. https://doi.org/10.1073/pnas.1914667117
Chaudhry, M. Zeeshan; Casalegno-Garduno, Rosaely; Sitnik, Katarzyna M.; Kasmapour, Bahram; Pulm, Ann-Kathrin; Brizić, Ilija; Eiz-Vesper, Britta; Moosmann, Andreas; Jonjić, Stipan; Mocarski, Edward S.; Cicin-Sain, Luka

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Chaudhry, M. Z., Casalegno Garduno, R., Sitnik, K. M., Kasmapour, B., Pulm, A. K., Brizić, I. ... Cicin Sain, L. (2020). Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proceedings of the National Academy of Sciences, 117. (23), 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry, M. Zeeshan, et al. "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells." Proceedings of the National Academy of Sciences, vol. 117, br. 23, 2020, str. 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M. Zeeshan, Rosaely Casalegno Garduno, Katarzyna M. Sitnik, Bahram Kasmapour, Ann Kathrin Pulm, Ilija Brizić, Britta Eiz Vesper, et al. "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells." Proceedings of the National Academy of Sciences 117, br. 23 (2020): 12961-12968. https://doi.org/10.1073/pnas.1914667117

Chaudhry, M. Z., et al. (2020) 'Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells', Proceedings of the National Academy of Sciences, 117(23), str. 12961-12968. doi: 10.1073/pnas.1914667117

Chaudhry MZ, Casalegno Garduno R, Sitnik KM, Kasmapour B, Pulm AK, Brizić I, i sur.. Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proceedings of the National Academy of Sciences [Internet]. 09.06.2020. [pristupljeno 05.05.2024.];117(23):12961-12968. doi: 10.1073/pnas.1914667117

M. Z. Chaudhry, et al., "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells", Proceedings of the National Academy of Sciences, vol. 117, br. 23, str. 12961-12968, Lipanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:594837. [Citirano: 05.05.2024.]

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Naslov (engleski)Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells
AutorM. Zeeshan Chaudhry
AutorRosaely Casalegno-Garduno
AutorKatarzyna M. Sitnik
AutorBahram Kasmapour
AutorAnn-Kathrin Pulm
AutorIlija Brizić
AutorBritta Eiz-Vesper
AutorAndreas Moosmann
AutorStipan Jonjić
AutorEdward S. Mocarski
AutorLuka Cicin-Sain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viral immune evasion is currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting antigen presentation pathways. We evaluated viral interference with the ultimate step in cytotoxic T cell function, the death of infected cells. The viral inhibitor of caspase-8 activation (vICA) conserved in human cytomegalovirus (HCMV) and murine CMV (MCMV) prevents the activation of caspase-8 and proapoptotic signaling. We demonstrate the key role of vICA from either virus, in deflecting antigen-specific CD8 T cell-killing of infected cells. vICA-deficient mutants, lacking either UL36 or M36, exhibit greater susceptibility to CD8 T cell control than mutants lacking the set of immunoevasins known to disrupt antigen presentation via MHC class I. This difference is evident during infection in the natural mouse host infected with MCMV, in settings where virus-specific CD8 T cells are adoptively transferred. Finally, we identify the molecular mechanism through which vICA acts, demonstrating the central contribution of caspase-8 signaling at a point of convergence of death receptor-induced apoptosis and perforin/granzyme-dependent cytotoxicity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 117, br. 23, str. 12961-12968
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1914667117
URN:NBNurn:nbn:hr:184:594837
Datum objave publikacije2020-06-09
URL dokumentahttp://www.pnas.org/lookup/doi/10.1073/pnas.1914667117
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-09-21 12:28:15