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Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells
Frontiers in Microbiology, 11 (2020); 1179. https://doi.org/10.3389/fmicb.2020.01179
Ouwendijk, Werner J. D.; Dekker, Lennard J. M.; van den Ham, Henk-Jan; Lenac Roviš, Tihana; Haefner, Erik S.; Jonjić, Stipan; Haas, Jürgen; Luider, Theo M.; Verjans, Georges M. G. M.

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Ouwendijk, W. J. D., Dekker, L. J. M., van den Ham, H. J., Lenac Roviš, T., Haefner, E. S., Jonjić, S. ... Verjans, G. M. G. M. (2020). Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Frontiers in Microbiology, 11.. doi: 10.3389/fmicb.2020.01179

Ouwendijk, Werner J. D., et al. "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells." Frontiers in Microbiology, vol. 11, 2020. https://doi.org/10.3389/fmicb.2020.01179

Ouwendijk, Werner J. D., Lennard J. M. Dekker, Henk Jan van den Ham, Tihana Lenac Roviš, Erik S. Haefner, Stipan Jonjić, Jürgen Haas, Theo M. Luider i Georges M. G. M. Verjans. "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells." Frontiers in Microbiology 11 (2020). https://doi.org/10.3389/fmicb.2020.01179

Ouwendijk, W. J. D., et al. (2020) 'Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells', Frontiers in Microbiology, 11. doi: 10.3389/fmicb.2020.01179

Ouwendijk WJD, Dekker LJM, van den Ham HJ, Lenac Roviš T, Haefner ES, Jonjić S, i sur.. Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Frontiers in Microbiology [Internet]. 29.05.2020. [pristupljeno 13.04.2024.];11. doi: 10.3389/fmicb.2020.01179

W. J. D. Ouwendijk, et al., "Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells", Frontiers in Microbiology, vol. 11, Svibanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:388402. [Citirano: 13.04.2024.]

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Podaci o radu
Naslov (engleski)Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells
AutorWerner J. D. Ouwendijk
AutorLennard J. M. Dekker
AutorHenk-Jan van den Ham
AutorTihana Lenac Roviš
AutorErik S. Haefner
AutorStipan Jonjić
AutorJürgen Haas
AutorTheo M. Luider
AutorGeorges M. G. M. Verjans
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) are two closely related human alphaherpesviruses that persistently infect most adults worldwide and cause a variety of clinically important diseases. Herpesviruses are extremely well adapted to their hosts and interact broadly with cellular proteins to regulate virus replication and spread. However, it is incompletely understood how HSV-1 and VZV interact with the host proteome during productive infection. This study determined the temporal changes in virus and host protein expression during productive HSV-1 and VZV infection in the same cell type. Results demonstrated the temporally coordinated expression of HSV-1 and VZV proteins in infected cells. Analysis of the host proteomes showed that both viruses affected extracellular matrix composition, transcription, RNA processing and cell division. Moreover, the prominent role of epidermal growth factor receptor (EGFR) signaling during productive HSV-1 and VZV infection was identified. Stimulation and inhibition of EGFR leads to increased and decreased virus replication, respectively. Collectively, the comparative temporal analysis of viral and host proteomes in productively HSV-1 and VZV-infected cells provides a valuable resource for future studies aimed to identify target(s) for antiviral therapy development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Microbiology
Brojčani podacivol. 11, 1179
e-ISSN1664-302X
DOIhttps://doi.org/10.3389/fmicb.2020.01179
URN:NBNurn:nbn:hr:184:388402
Datum objave publikacije2020-05-29
URL dokumentahttps://www.frontiersin.org/article/10.3389/fmicb.2020.01179/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-09-17 16:50:53