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The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.
Viruses, 7 (2015), 8; 4582-601. https://doi.org/10.3390/v7082834
Steingruber, M; Socher, E; Hutterer, C; Webel, R; Bergbrede, T; Lenac, Tihana; Sticht, H; Marschall, M

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Steingruber, M., Socher, E., Hutterer, C., Webel, R., Bergbrede, T., Lenac, T. ... Marschall, M. (2015). The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.. Viruses, 7. (8), 4582-601. doi: 10.3390/v7082834

Steingruber, M, et al. "The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.." Viruses, vol. 7, br. 8, 2015, str. 4582-601. https://doi.org/10.3390/v7082834

Steingruber, M, E Socher, C Hutterer, R Webel, T Bergbrede, Tihana Lenac, H Sticht i M Marschall. "The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.." Viruses 7, br. 8 (2015): 4582-601. https://doi.org/10.3390/v7082834

Steingruber, M., et al. (2015) 'The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.', Viruses, 7(8), str. 4582-601. doi: 10.3390/v7082834

Steingruber M, Socher E, Hutterer C, Webel R, Bergbrede T, Lenac T, i sur.. The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.. Viruses [Internet]. 2015. [pristupljeno 20.01.2025.];7(8):4582-601. doi: 10.3390/v7082834

M. Steingruber, et al., "The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.", Viruses, vol. 7, br. 8, str. 4582-601, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:583296. [Citirano: 20.01.2025.]

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Naslov (engleski)The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain.
AutorM Steingruber
AutorE Socher
AutorC Hutterer
AutorR Webel
AutorT Bergbrede
AutorTihana Lenac
AutorH Sticht
AutorM Marschall
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification. The HCMV-encoded protein kinase pUL97 acts as a CDK ortholog showing structural and functional similarities. Recently, we reported an interaction between pUL97 kinase with a subset of host cyclins, in particular with cyclin T1. Here, we describe an interaction of pUL97 at an even higher affinity with cyclin B1. As a striking feature, the interaction between pUL97 and cyclin B1 proved to be strictly dependent on pUL97 activity, as interaction could be abrogated by treatment with pUL97 inhibitors or by inserting mutations into the conserved kinase domain or the nonconserved C-terminus of pUL97, both producing loss of activity. Thus, we postulate that the mechanism of pUL97-cyclin B1 interaction is determined by an active pUL97 kinase domain.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 7, br. 8, str. 4582-601
p-ISSN1999-4915
DOIhttps://doi.org/10.3390/v7082834
URN:NBNurn:nbn:hr:184:583296
Datum objave publikacije2015
URL dokumentahttp://bib.irb.hr/821462
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-04-19 14:42:43