prikaz prve stranice dokumenta The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium
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The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium
American Journal of Reproductive Immunology, 81 (2019), 5; e13104. https://doi.org/10.1111/aji.13104
Mulac‐Jeričević, Biserka; Šućurović, Sandra; Gulić, Tamara; Szekeres‐Bartho, Julia

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Mulac‐Jeričević, B., Šućurović, S., Gulić, T. i Szekeres‐Bartho, J. (2019). The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium. American Journal of Reproductive Immunology, 81. (5). doi: 10.1111/aji.13104

Mulac‐Jeričević, Biserka, et al. "The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium." American Journal of Reproductive Immunology, vol. 81, br. 5, 2019. https://doi.org/10.1111/aji.13104

Mulac‐Jeričević, Biserka, Sandra Šućurović, Tamara Gulić i Julia Szekeres‐Bartho. "The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium." American Journal of Reproductive Immunology 81, br. 5 (2019). https://doi.org/10.1111/aji.13104

Mulac‐Jeričević, B., et al. (2019) 'The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium', American Journal of Reproductive Immunology, 81(5). doi: 10.1111/aji.13104

Mulac‐Jeričević B, Šućurović S, Gulić T, Szekeres‐Bartho J. The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium. American Journal of Reproductive Immunology [Internet]. 22.03.2019. [pristupljeno 13.11.2024.];81(5). doi: 10.1111/aji.13104

B. Mulac‐Jeričević, S. Šućurović, T. Gulić i J. Szekeres‐Bartho, "The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium", American Journal of Reproductive Immunology, vol. 81, br. 5, Ožujak 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:677164. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:677164
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Naslov (engleski)The involvement of the progesterone receptor in PIBF and Gal‐1 expression in the mouse endometrium
AutorBiserka Mulac‐Jeričević
AutorSandra Šućurović
AutorTamara Gulić
AutorJulia Szekeres‐Bartho
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Problem: The progesterone-regulated genes, PIBF and Gal‐1, are key players in the feto-maternal immunological interaction. This study aims to investigate the expression of PIBF and Gal‐1 in WT and progesterone receptor KO models as well as subsequent effects of PIBF on decidualization of stromal cells. Method of the study: PRAKO, PRBKO and PRKO BALB/c mice were used for assessing the role of PR isoforms in PIBF induction. PIBF‐ and Gal‐1 mRNA expression in the uterus was tested by real‐time PCR. The effect of PIBF on decidualization of endometrial stromal cells was verified by anti-desmin immunofluorescence. Immunohistochemistry was used for testing PIBF expression in the uterus. Gal‐1, ERα and PR positive decidual NK cells were detected by immunofluorescence. Results: PIBF mRNA was significantly increased in progesterone‐treated WT mice, but not in PRKO and PRAKO mice. PIBF protein expression was reduced in the endometria of PRKO and PRAKO, but not in PRBKO mice. During a 6‐day culture, PIBF induced decidual transformation of endometrial stromal cells. PIBF expression in the mouse uterus was highest during the implantation window, while Gal‐1 mRNA expression continuously increased between day 2.5 and day 11.5 of gestation. Decidual NK cells express Gal‐1 and ERα, but not PR at day 7.5 murine pregnancy. Conclusion: PIBF produced via engagement of PRA, is highly expressed in the endometrium during the implantation window, and plays a role in decidualization. The concerted action of PIBF and Gal‐1 might contribute to the low cytotoxic activity of decidual NK cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 81, br. 5, e13104
p-ISSN1046-7408
e-ISSN1600-0897
DOIhttps://doi.org/10.1111/aji.13104
URN:NBNurn:nbn:hr:184:677164
Datum objave publikacije2019-03-22
URL dokumentahttps://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13104
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-03-30 14:29:07