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Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling
Diabetes Care, 43 (2019), 2; 494-196. https://doi.org/10.2337/dc19-1888
Turk Wensveen, Tamara; Fučkar Čupić, Dora; Jurišić Eržen, Dubravka; Polić, Bojan; Wensveen, Felix M.

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Turk Wensveen, T., Fučkar Čupić, D., Jurišić Eržen, D., Polić, B. i Wensveen, F. M. (2019). Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling. Diabetes Care, 43. (2), 494-196. doi: 10.2337/dc19-1888

Turk Wensveen, Tamara, et al. "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling." Diabetes Care, vol. 43, br. 2, 2019, str. 494-196. https://doi.org/10.2337/dc19-1888

Turk Wensveen, Tamara, Dora Fučkar Čupić, Dubravka Jurišić Eržen, Bojan Polić i Felix M. Wensveen. "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling." Diabetes Care 43, br. 2 (2019): 494-196. https://doi.org/10.2337/dc19-1888

Turk Wensveen, T., et al. (2019) 'Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling', Diabetes Care, 43(2), str. 494-196. doi: 10.2337/dc19-1888

Turk Wensveen T, Fučkar Čupić D, Jurišić Eržen D, Polić B, Wensveen FM. Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling. Diabetes Care [Internet]. 2019. [pristupljeno 04.12.2024.];43(2):494-196. doi: 10.2337/dc19-1888

T. Turk Wensveen, D. Fučkar Čupić, D. Jurišić Eržen, B. Polić i F. M. Wensveen, "Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling", Diabetes Care, vol. 43, br. 2, str. 494-196, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:925629. [Citirano: 04.12.2024.]

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Naslov (engleski)Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell–Mediated Tissue Remodeling
AutorTamara Turk Wensveen
AutorDora Fučkar Čupić
AutorDubravka Jurišić Eržen
AutorBojan Polić
AutorFelix M. Wensveen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
CASE SUMMARY A female patient age 69 years with .10-year history of type 2 diabetes (T2D), on a therapy of premixed aspart insulin, presented with poor glycemic control (HbA1c 8.7%). Change of therapy to three injections of short- acting aspart and once-daily glargine improved glycemic control but resulted in severe lipoatrophy at all sites of injection, a rare complication of insulin therapy almost exclusively associated with type 1 diabetes (T1D). The patient had C-peptide levels within normal range and lacked autoantibodies against GAD, islet antigen 2 (IA-2), and tissue transglutaminase (tTg), excluding T1D. Glargine injection was replaced by degludec, but this did not prevent formation of new indentures. Histological analysis of tissue biopsies revealed strong tissue remodeling at affected sites including fibrosis, reduction of adipocyte size, and increased vascularization. Immunohistochemical staining showed a strong influx of CD4 T cells in affected sites but no apparent signs of T cell–mediated cell death. Flow cytometry of peripheral blood leukocytes did not show an overt effector cell profile of CD4 T cells, indicating that the response was mediated locally. Our findings indicate that insulin-induced lipoatrophy in the context of T2D is distinct from that seen in T1D and appears to depend on CD4 T cell–mediated tissue remodeling.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiabetes Care
Brojčani podacivol. 43, br. 2, str. 494-196
p-ISSN0149-5992
DOIhttps://doi.org/10.2337/dc19-1888
URN:NBNurn:nbn:hr:184:925629
Datum objave publikacije2019
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Kratica: T-MEMORY
Voditelj: Felix Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: uniri-biomed-18-117
Naziv (hrvatski): Direktni utjecaj hipoglikemija na promjene srčanog ritma u bolesnika sa šećernom bolesti tip 2
Naziv (engleski): Direct impact of hypoglycaemia on heart rhythm in patients with diabetes mellitus type 2
Voditelj: Tamara Turk Wensveen
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/1047236
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2020-03-30 08:31:25