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The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
The Journal of Experimental Medicine, 216 (2019), 8; 1809-1827. https://doi.org/10.1084/jem.20182213
Železnjak, Jelena; Lisnić, Vanda Juranić; Popović, Branka; Lisnić, Berislav; Babić, Marina; Halenius, Anne; L’Hernault, Anne; Roviš, Tihana Lenac; Hengel, Hartmut; Erhard, Florian; Redwood, Alec J.; Vidal, Silvia M.; Dölken, Lars; Krmpotić, Astrid; Jonjić, Stipan Više autora...

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Železnjak, J., Lisnić, V. J., Popović, B., Lisnić, B., Babić, M., Halenius, A. ... Jonjić, S. (2019). The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. The Journal of Experimental Medicine, 216. (8), 1809-1827. doi: 10.1084/jem.20182213

Železnjak, Jelena, et al. "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors." The Journal of Experimental Medicine, vol. 216, br. 8, 2019, str. 1809-1827. https://doi.org/10.1084/jem.20182213

Železnjak, Jelena, Vanda Juranić Lisnić, Branka Popović, Berislav Lisnić, Marina Babić, Anne Halenius, Anne L’Hernault, et al. "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors." The Journal of Experimental Medicine 216, br. 8 (2019): 1809-1827. https://doi.org/10.1084/jem.20182213

Železnjak, J., et al. (2019) 'The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors', The Journal of Experimental Medicine, 216(8), str. 1809-1827. doi: 10.1084/jem.20182213

Železnjak J, Lisnić VJ, Popović B, Lisnić B, Babić M, Halenius A, i sur.. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. The Journal of Experimental Medicine [Internet]. 05.08.2019. [pristupljeno 13.04.2024.];216(8):1809-1827. doi: 10.1084/jem.20182213

J. Železnjak, et al., "The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors", The Journal of Experimental Medicine, vol. 216, br. 8, str. 1809-1827, Kolovoz 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:650034. [Citirano: 13.04.2024.]

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Naslov (engleski)The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
AutorJelena Železnjak
AutorVanda Juranić Lisnić
AutorBranka Popović
AutorBerislav Lisnić
AutorMarina Babić
AutorAnne Halenius
AutorAnne L’Hernault
AutorTihana Lenac Roviš
AutorHartmut Hengel
AutorFlorian Erhard
AutorAlec J. Redwood
AutorSilvia M. Vidal
AutorLars Dölken
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However, the lack of MHC I on the cell surface renders the infected cell susceptible to NK cell killing upon missing self recognition. To counter this, mouse CMV (MCMV) rescues some MHC I molecules to engage inhibitory Ly49 receptors. Here we identify a new viral protein, MATp1, that is essential for MHC I surface rescue. Rescued altered-self MHC I molecules show increased affinity to inhibitory Ly49 receptors, resulting in inhibition of NK cells despite substantially reduced MHC I surface levels. This enables the virus to evade recognition by licensed NK cells. During evolution, this novel viral immune evasion mechanism could have prompted the development of activating NK cell receptors that are specific for MATp1-modified altered-self MHC I molecules. Our study solves a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I–restricted Ly49 receptors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Experimental Medicine
Brojčani podacivol. 216, br. 8, str. 1809-1827
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20182213
URN:NBNurn:nbn:hr:184:650034
Datum objave publikacije2019-08-05
ProjektŠifra: G1002523
Naziv (engleski): Regulatory role of non-coding RNAs in herpesvirus infections
Pravna nadležnost: Ujedinjena Kraljevina
Financijer: RCUK
Linija financiranja: MRC
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://rupress.org/jem/article/216/8/1809/120585/The-complex-of-MCMV-proteins-and-MHC-class-I
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2020-02-19 16:24:25